摘要
目的探讨癌结节对Ⅲ期大肠癌患者生存状况的影响。方法Ⅲ期大肠癌患者500例,其中无癌结节组228例,癌结节组272例;两组均给予相同的手术治疗和辅助化疗。随访3年,比较两组患者的肿瘤分化程度、发生神经侵犯、肿瘤复发或转移情况和复发时间。结果无癌结节组患者低分化程度比例(22.4%)低于癌结节组(36.4%),无癌结节组肿瘤发生神经侵犯比例(15.6%)低于癌结节组(29.6%),差异均有统计学意义(P<0.05);随访3年后,无癌结节组患者术后发生肿瘤复发或转移率(24.6%)低于癌结节组(37.1%),无癌结节组患者术后肿瘤复发的时间(10.5±3.8月)长于癌结节组(7.2±2.9月),差异均有统计学意义(P<0.05)。结论癌结节可能与患者的神经侵犯和肿瘤分化程度有关,一定程度上对患者的术后无病生存率和无病生存时间有影响,影响Ⅲ期大肠癌患者的生存质量。
Objective To understand the effect of cancer nodules on the survival status of stage Ⅲ colorectal cancer.Methods A total of 500 patients with stage Ⅲ colorectal cancer were first chosen as the subjects of study,which included228 cases of cancer-free nodules（group A） and 272 cases of cancer nodules（group B）.Both groups were treated with surgery and chemotherapy of the same kind.Follow-ups were conducted in the following three years.Tumor differentiation,occurrence of nerve invasion,tumor recurrence or metastasis and recurrence time of the two groups were compared.Results The percentage of patients with non-cancerous nodules was lower than that with cancerous nodules（22.4% vs.36.4%）,while those without cancerous nodules（15.6%） were lower than those with cancerous nodules（29.6%）（P〈0.05）.After 3 years of follow-up,the incidence of tumor recurrence or metastasis（24.6%） in patients without cancer nodules was lower than that in cancer nodules（37.1%） and no cancer nodules.The time of tumor recurrence in group A（10.5±3.8 months） was longer than that in group B（7.2±2.9 months）.The difference was statistically significant（P〈0.05）.Conclusions Cancer nodules bear relevance to the extent of tumor differentiation and nerve invasion.They may impose significant threat on the survival rate and the quality of life of patients with stage Ⅲcolorectal cancer.
作者
陈福森
夏恒
邱海江
CHEN Fu-sen;XIA Heng;QIU Hai-jiang(Department of General Surgery,Shaoxing center hospital,Shaoxing 312000,China)
出处
《健康研究》
CAS
2018年第4期361-363,共3页
Health Research
关键词
癌结节
大肠癌
病理分期
cancer nodule
colorectal cancer
pathological stage
