摘要
目的探讨淋巴结转移度对Ⅲ期大肠癌患者手术后发生远处转移的影响情况。方法选取153例Ⅲ期大肠癌患者,采用回顾性调查的方法,分析淋巴结转移度对患者术后转移情况及5年生存率的影响。结果淋巴结转移度≤0.02的Ⅲ期大肠癌患者术后发生远处转移的占34.29%,远低于淋巴结转移度>0.02患者的85.42%,差异具有统计学意义,P<0.05。肿瘤分化情况和淋巴结转移度是患者手术后发生远处转移的危险因素,P<0.05;淋巴结转移度较高的患者术后发生远处转移比例较高,术后生存时间及5年生存率均较低,差异具有统计学意义,P<0.05。结论淋巴结转移度越高,Ⅲ期大肠癌患者手术后发生远处转移的可能性越大,术后生存时间越短。检测淋巴结转移度可以很好地预测大肠癌患者预后情况,值得临床推广。
Objective 153 cases of stage Ⅲ colorectal cancer patients were retrospectively analyzed.Effect of lymph node ratio on distant metastasis and 5-year survival rate were analyzed.Methods Steroid saponins of the flowers of Cestrum Nocturnum,Linn(SSFCN) were separated and identified their structures by solvent.The K562 cells were cultured in vitro and the cell growth inhibition was measured by MTT assay after treatment with SSFCN,The effect of SSFCN on apoptotic induction in K562 cells was determined using the DNA ladder agarose gel electrophoresis.Alteration of cell cycle and apoptosis rate was defected by flow cytometry.The expression of AKt,and phosphorylated AKt(p-AKt) was detected by Western blot.Results Lymph node metastasis rate of stage Ⅲ colorectal cancer patients with lymph node ratio ≤0.02 was 34.29%,which was lower than patients with lymph node ratio > 0.02(85.42%),the difference was statistically significant,P < 0.05.Tumor differentiation and lymph node metastasis rate were risk factors for distant metastasis after surgery,P < 0.05; Patients with higher degree of lymph node metastasis had higher proportion of distant metastasis,and lower survival time,and 5-year survival rate,the difference was statistically significant,P < 0.05.Conclusion The higher the degree of lymph node metastasis,the greater the possibility of distant lymph node metastasis in stage Ⅲ colorectal cancer patients after surgery,and the shorter the survival time.Detection of lymph node metastasis rate can be a good predictor of the prognosis of patients with colorectal cancer,it is worthy of promotion.
出处
《实用癌症杂志》
2015年第4期556-558,562,共4页
The Practical Journal of Cancer
关键词
淋巴结转移度
大肠癌
远处转移
5年生存率
Lymph node ratio
Colorectal cancer
Distant metastasis
5-year survival
