摘要
目的观察三黄胶囊内服联合金黄膏外敷治疗湿热痹阻型急性痛风性关节炎的临床疗效。方法将60例湿热痹阻型急性痛风性关节炎患者随机分为治疗组和对照组,每组30例。对照组予双氯芬酸钠口服,治疗组在对照组治疗措施基础上加用三黄胶囊口服加金黄膏外敷。两组疗程均为10日,观察临床疗效,比较中医证候积分、视觉模拟评分(疼痛与活动受限)、关节肿胀评分及相关生化指标血尿酸(BUA)、红细胞沉降率(ESR)、C反应蛋白(CRP)水平的变化情况。结果①治疗组、对照组临床总有效率分别为93.33%、70.00%;组间临床疗效比较,治疗组明显优于对照组(P<0.05)。②组间治疗后比较,中医证候积分差异有统计学意义,治疗组明显较对照组更低(P<0.05)。③组间治疗后比较,疼痛、活动受限视觉模拟评分及关节肿胀评分差异有统计学意义,治疗组明显低于对照组(P<0.05)。④组间治疗后比较,BUA、ESR及CRP水平差异有统计学意义,治疗组明显低于对照组(P<0.05)。结论三黄胶囊内服联合金黄膏外敷结合西药治疗湿热痹阻型急性痛风性关节炎,可明显缓解临床症状,降低血尿酸水平。
Objective To observe the clinical efficacy of Sanhuang Capsule combined with Jinhuang Ointment in the treatment of acute gouty arthritis with syndrome of dampness-heat blockage. Methods 60 patients of acute gouty arthritis with syndrome of dampness-heat blockage were randomly divided into the treatment group and control group,30 cases in each group. The control group was orally treated with diclofenac sodium,and the treatment group was additionally treated with Sanhuang Capsule for oral administration and Jinhuang Ointment for external application based on the treatment for the control group,with a course of 10 days. The clinical efficacy was observed,and the changes of TCM syndrome score,visual analogue scale( VAS) scores( pain and activity limitation),score of joint swelling and the levels of the related biochemical indexes including blood uric acid( BUA),erythrocyte sedimentation rate( ESR) and C reactive protein( CRP) were compared. Results(1) The clinical tota1 effective rate was 93. 33% in the treatment group and 70. 00% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group( P < 0. 05).(2)After treatment,there was statistically significant difference on TCM syndrome score between the two groups,and the score of the treatment group was obviously lower than that of the control group( P < 0. 05).(3)After treatment,there were statistically significant differences on the VAS scores of pain and activity limitation and the score of joint swelling between the two groups,and the scores of the treatment group were significantly lower than those of the control group( P < 0. 05).(4)After treatment,there were statistically significant differences on the levels of BUA,ESR and CRP between the two groups,and the levels of the treatment group were significantly lower than those of the control group( P < 0. 05). Conclusion Sanhuang Capsule with oral administration and Jinhuang Ointment with external application combined with western medicine can be used in
出处
《上海中医药杂志》
2017年第8期62-64,67,共4页
Shanghai Journal of Traditional Chinese Medicine
关键词
痛风性关节炎
湿热痹阻证
三黄胶囊
金黄膏
血尿酸
关节胀痛
gouty arthritis
syndrome of dampness-heat blockage
Sanhuang Capsule
Jinhuang Ointment
blood uric acid
joint swelling pain
