摘要
目的 探讨短暂性脑缺血发作 (transientischemicattack ,TIA)对脑梗死患者是否具有脑保护效应。 方法 收集有或无同侧TIAs史的首次脑梗死患者分别 18例和 31例 ,利用酶联免疫分析法测定入院时血清中神经元特异性烯醇化酶 (neuro specificenolase ,NSE)的含量水平 ,并采用改良爱丁堡 斯堪的那维亚卒中量表和半定量的 5级评分法分别对患者入院时及 1月后神经功能状态进行评估。 结果 入院时NSE水平和神经功能缺损程度呈明显正相关 (有TIAs史组r =0 72 8,P <0 0 1;无TIAs史组r =0 6 83,P <0 0 1) ,且有TIAs史的脑梗死患者NSE的含量明显低于无TIAs史组 (P <0 0 1) ,有TIAs史组入院时及 1月后神经功能状态与单纯脑梗死组相比差异也均有显著性 (P <0 0 5 )。 结论 TIA可能对人脑产生缺血耐受作用 ,从而减轻随后严重脑缺血的神经功能缺损程度 ,改善脑梗死的预后。
Objective To evaluate whether transient ischemic attacks (TIAs) have neuroprotective effects on patients with cerebral infarction. Methods A total of patients with first-ever cerebral infarction in the anterior circulation admitted to hospital were divided into two groups on the basis of the presence or absence of prior ipsilateral TIAs. The serum neuro-specific enolase (NSE) levels were determined by ELISIA on admission, and the severity of the neurological picture on admission and functional disability after stroke for a month were compared between patients with and without TIAs. Results Patients without prior TIAs had a more severe clinical picture and higher levels of NSE on admission, and there were positive correlations?between NSE and the degree of neurological deficit. Patients with previous TIAs had a more favorable outcome than those without TIAs. Conclusions This study suggests that ischemic tolerance may play a role in patients with ipsilateral TIAs before cerebral infarction, allowing better recovery from a subsequent ischemic stroke.
出处
《实用老年医学》
CAS
2003年第4期189-191,共3页
Practical Geriatrics
关键词
脑缺血
缺血耐受
烯醇化酶
预后
Brain ischemia
Ischemic tolerance
Enolase
Prognosis
