摘要
目的探讨预先短暂性脑缺血发作(TIA)是否对后继脑梗死具有神经保护作用。方法根据脑梗死患者是否预先发生同侧的TIA分为TIA组和无TIA组,分别从TIA持续时间、发作次数、与脑梗死间隔时间及梗死部位几方面同无TIA组比较,采用ADL评分标准,评定患者预后恢复情况。结果Ⅰ级预后预先有TIA的占72%,无TIA的占63%,二者相比差异无显著性(X^2=3．31,P＞0．05)。但脑梗死前有TIA且持续时间在5～20min、发作次数2～3次,与脑梗死间隔不超过1周者,其Ⅰ级预后较多,同无TIA组相比较差异有显著性(P＜0．05)。结论脑梗死前发生的TIA有可能对人脑产生缺血耐受作用。TIA的神经保护性与其发作持续时间、发作次数及与脑梗死间隔时间有一定关系。
Objective To study whether transient ischemic attack （TIA） in advance has the neuroprotective effect on subsequant cerebral infarction. Methods According to whether they had ipsilateral TIA in advance, 638 patients were divided into 2 groups： TIA group and non-TIA group. The 2 groups were compared in such aspects as the attack duration, frequency, and the interval and site of cerebral infarction. The neurologic impairment was evaluated according to the activities of daily living （ADL） scores. Results Patients with prior TIA had a more favorable outcome than those without TIA （72% vs 63%）, but the difference between these 2 groups was not significant （χ^2=3.31 ,P〉0.05）, while the patients with prior TIA lasting 5-20 min, for 2-3 times and at 1-week or short intervals were significantly different from non-TIA group in the prognosis （P〈0.05）. Conclusion TIA which happens before cerebral infarction may have ischemic tolerance effects on brains, and the neuroprotection of TIA is associated with the duration and the frequency of TIA and the interval between TIA and cerebral infarction.
出处
《中华神经医学杂志》
CAS
CSCD
2006年第7期728-730,共3页
Chinese Journal of Neuromedicine
关键词
短暂性脑缺血发作
缺血耐受
脑梗死
预后
Transient ischemic attacks
Ischemic tolerance
Cerebral infarction
Prognosis
