摘要
目的:观察清热祛湿方保留灌肠联合美沙拉嗪对大肠湿热型溃疡性直肠炎活动期患者凝血功能及炎性细胞因子的影响。方法:84例大肠湿热型溃疡性直肠炎活动期患者按照随机数字表法分为观察组和对照组,每组42例。对照组给予美沙拉嗪肠溶片治疗,观察组在对照组的基础上予以清热祛湿方保留灌肠治疗,2组连续治疗4周。观察记录2组临床症状评分(腹痛、腹泻、黏液脓血便)、凝血功能指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)及D-二聚体(DD)]、血清炎性细胞因子[白细胞介素-6 (IL-6)、白细胞介素-8 (IL-8)、白细胞介素-10 (IL-10)]的改善情况,并比较2组临床疗效。结果:观察组总有效率为90.48%,显著高于对照组71.42%(χ~2=4.941,P <0.05)。治疗后,2组腹痛、腹泻、黏液脓血便积分较治疗前均降低(P <0.05);观察组治疗后腹痛、腹泻、黏液脓血便积分均低于对照组(P <0.05)。治疗后,2组PT、APTT、FIB、D-D指标较治疗前均降低(P <0.05);观察组治疗后PT、APTT、FIB、D-D指标均低于对照组(P <0.05)。治疗后,2组血清IL-6、IL-8水平较治疗前均降低(P <0.05),IL-10水平较治疗前均升高(P <0.05);观察组血清炎性细胞因子水平改善均优于对照组(P <0.05)。结论:清热祛湿方保留灌肠联合美沙拉嗪能够调节大肠湿热型溃疡性直肠炎活动期患者凝血功能指标和血清炎性细胞因子表达,有助于缓解患者临床症状,促进疾病的康复。
Objective:To observe the effect of retention enema with Qingre Qushi prescription combined with mesalazine on the coagulation function and inflammatory cytokines of patients with ulcerative proctitis of large intestinal dampness-heat type at active stage.%Methods:A total of 84 cases of patients with ulcerative proctitis of large intestinal dampness-heat type at active stage were divided into the observation group and the control group according to the random number table method,42 cases in each group.The control group was treated with mesalazine enteric-coated tablets,and the observation group was additionally treated with retention enema with Qingre Qushi prescription based on the treatment of the control group.Both groups were treated for four weeks.The improvement of the scores of clinical symptoms including abdominal pain,diarrhea as well as stool containing mucus,pus and blood,the indexes of the coagulation function including prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB)and D-dimer(D-D),and the inflammatory cytokines in serum including interleukin-6(IL-6),interleukin-8(IL-8)and interleukin-10(IL-10)in the two groups was observed and recorded;the clinical effect in the two groups was compared.Results:The total effective rate was 90.48%in the observation group,significantly higher than that of 71.42%in the control group(χ~2=4.941,P<0.05).After treatment,the scores of abdominal pain,diarrhea and mucus and stool containing mucus,pus and blood in the two groups were decreased when compared with those before treatment(P<0.05);the above scores in the observation group were lower than those in the control group(P<0.05).After treatment,the indexes of PT,APTT,FIB and D-D in the two groups were decreased when compared with those before treatment(P<0.05);the above indexes in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of IL-6 and IL-8 in serum in the two groups were decreased when compared with those before treatment(P<0.05),whil
出处
《新中医》
CAS
2019年第10期110-114,共5页
New Chinese Medicine
关键词
溃疡性直肠炎活动期
大肠湿热型
清热祛湿方
保留灌肠
美沙拉嗪
凝血功能
炎性细胞因子
Ulcerative proctitis at active stage
Large intestinal dampness-heat type
Qingre Qushi prescription
Retention enema
Mesalazine
Coagulation function
Inflammatory cytokines
