摘要
目的:探讨银黄清肺胶囊联合阿奇霉素治疗肺经风热型急性鼻窦炎的临床疗效及血清肿瘤坏死因子(TNF)-α、白细胞介素2 (IL-2)水平的影响。方法:将急性鼻窦炎患者68例随机分为2组各34例;对照组予阿奇霉素片口服及鼻炎喷剂喷鼻,治疗组在对照组基础上口服银黄清肺胶囊;2组均连续治疗2周,比较2组中医证候评分和临床疗效,检测2组治疗前后血清TNF-α、IL-2水平。结果:总有效率治疗组为97.06%,对照组为76.47%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组患者鼻塞、鼻涕、头痛、鼻黏膜充血、鼻甲肿大等中医证候评分均较治疗前明显降低(P <0.05);且治疗组上述各项评分明显低于对照组(P <0.05)。治疗后,2组血清TNF-α、IL-2水平均较治疗前明显降低(P <0.05);且治疗组TNF-α、IL-2水平明显低于对照组(P <0.05)。结论:银黄清肺胶囊联合阿奇霉素治疗肺经风热证急性鼻窦炎疗效优于单纯西药治疗,其下调血清TNF-α、IL-2水平可能是起效机制之一。
Objective:To explore the clinical effect of Yinhuang Qingfei capsule combined with azithromycin for acute sinusitis of wind-heat in the lung meridian type,and its effect on the levels of serum tumor necrosis factor(TNF)-αand interleukin(IL)-2.Methods:Divided 68 cases of patients with acute sinusitis into two groups randomly,34 cases each group.The control group received azithromycin tablets via oral administration and rhinitis spray via nasal spray,while the treatment group additionally received Yinhuang Qingfei capsules via oral administration.The treatment for both groups lasted for 2 weeks continuously.Compared the symptom scores and clinical effect of patients in both groups,and detected the levels of serum TNF-αand IL-2 in both groups before and after treatment.Results:The total effective rate was 97.06%in the treatment group and 76.47%in the control group,difference being significant(P<0.05).After treatment,the scores of such symptoms as nasal obstruction,nasal discharge,headache,nasal mucosal congestion and nasal thyroid enlargement in both groups were significantly lower than those before treatment(P<0.05);each score above in the treatment group was significantly lower than that in the control group(P<0.05).After treatment,the levels of TNF-αand IL-2 in both groups were significantly lower than those before treatment(P<0.05);the levels of TNF-αand IL-2 in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion:Yinhuang Qingfei capsule combined with azithromycin has better clinical effect than simple western medicine in treating acute sinusitis of wind-heat in the lung meridian type.One of its functional mechanisms may be down-regulating the levels of serum TNF-αand IL-2.
作者
邱红艳
陈玲
QIU Hongyan;CHEN Ling
出处
《新中医》
CAS
2019年第5期238-240,共3页
New Chinese Medicine
关键词
急性鼻窦炎
肺经风热证
银黄清肺胶囊
阿奇霉素
Acute sinusitis
Wind-heat in the lung meridian syndrome
Yinhuang Qingfei capsule
Azithromycin
