摘要
目的探讨妊娠期肝内胆汁淤积症(ICP)患者的糖脂代谢水平变化特点及对围产结局的影响。方法回顾性收集2015年1月至2016年8月于广东省妇幼保健院产检并分娩的ICP患者资料173例,其中轻度ICP组94例,重度ICP组79例,选择同期正常孕妇164例作为对照组,比较三组血糖和血脂指标及围产结局。结果 ICP组孕妇与对照组比较,糖耐量1 h、糖耐量2 h、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL?C)、血清游离脂肪酸(FFAS)水平均升高,差异均有统计学意义(P<0.05),高密度脂蛋白(HDL?C)水平差异无统计学意义(P>0.05)。重度ICP组糖耐量1 h、糖耐量2 h、TG、TC、LDL?C水平均明显高于轻度ICP组,而HDL?C低于轻度ICP组(P<0.05)。重度ICP组早产率、胎儿宫内窘迫率、入住ICU率均高于轻度ICP重度ICP组和轻度ICP组剖宫产率和入住ICU率均高于对照组。结论 ICP孕妇易出现糖脂代谢异常,重度ICP患者更容易出现不良围产结局,需引起重视,孕期应加强血糖及血脂监测。
Objective To explore the characteristic of glucolipid metabolism and pregnancy outcome in women with intrahepatic cholestasis of pregnancy(ICP). Methods 173 women with ICP were recruited,who visited the Guangdong Maternal and Child Health Hospital for maternity and child care and delivery from January 2015 to August 2016. 79 women with severe ICP were in the severe ICP group and 94 women with mild ICP were included in the mild ICP group. Another164 normal pregnant women in the same period were in the control group. Levels of blood glucose and blood lipid and the pregnancy outcomes were compared in the three groups. Results Levels of oral glucose tolerance test(OGTT)1 hour and2 hour,triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL?C)and serum free fatty acids(FFAS)of women in both severe and mild ICP groups were all significantly higher than those in control group(P<0.05);there was no statistically significant difference in high density lipoprotein cholesterol(HDL?C)(P>0.05). Levels of OGTT 1 hour and 2 hour,TG,TC,LDL?C of women in severe ICP group were all significantly higher than mild ICP group,HDL?C was lower than mild ICP group(P<0.05). Compared with normal group and mid ICP group,the incidences of premature birth,fetal distress,check in ICU rate of the severe ICP group were significantly higher,but the delivery gestational weeks were significantly lower(P<0.05). The incidences of caesarean section and check in ICU rate in severe ICP and mild ICP groups were higher than those of normal group. Conclusion Pregnant women with ICP were more prone to abnormal glucose and lipid metabolism. Severe ICP patients were more likely to have adverse perinatal outcomes,which should be paid more attention and strengthen the management of perinatal.
作者
唐玲玲
刁福强
罗有文
赖卫明
刘成义
TANG Ling-ling;DIAO Fu-qiang;LUO You-wen;LAI Wei-ming;LIU Cheng-yi(Department of Laboratory,Guangdong Maternal and Child Health Hospital,Guangzhou,Guangdong 511400,China)
出处
《热带医学杂志》
CAS
2019年第2期229-232,共4页
Journal of Tropical Medicine
关键词
妊娠期肝内胆汁淤积症
糖脂代谢
妊娠结局
Intrahepatic cholestasis of pregnancy
Glucolipid metabolism
Pregnancy outcome
