摘要
目的分析妊娠期肝内胆汁淤积症(ICP)患者血脂水平、雌激素水平变化情况。方法选择山西省人民医院2014年4月至2018年4月收治的60例ICP患者作为观察组,另外选取同时期于本院接受健康体检的妊娠期女性100例作为对照组。检测并比较两组雌激素、血脂指标、肝功能水平及新生儿结局。结果观察组雌二醇、雌三醇水平分别为(62.35±13.95)、(45.48±19.57)ng/L,均高于对照组的(41.66±8.65)、(28.86±11.19)ng/L(P<0.05)。观察组总胆固醇、三酰甘油、低密度脂蛋白均高于对照组,观察组高密度脂蛋白低于对照组(P<0.05)。观察组总胆汁酸、天门冬氨酸氨基转移酶、总胆红素、丙氨酸氨基转移酶均高于对照组(P<0.05)。观察组胎儿宫内窘迫、新生儿窒息、早产儿发生率分别为15.00%、13.33%、16.67%,对照组分别为2.00%、1.00%、2.00%,两组比较差异有统计学意义(P<0.05);但观察组围生儿死亡率(1.67%)与对照组(0)比较差异未见统计学意义(P>0.05)。结论ICP患者血脂及雌激素水平均有异常改变,及时检测血脂及雌激素水平以发现患者的血脂及雌激素异常,有助于临床尽早开展干预,减少不良新生儿结局。
Objective To analyze the levels of blood lipid and estrogenin patients with intrahepatic cholestasis of pregnancy(ICP).Methods Sixty patients with ICP who were hospitalized in Shanxi Provincial People’s Hospital from April 2014 to April 2018 were selected as observation group.Another 100 pregnant women who received a physical examination at the same time in the same hospital were selected as control group.Estrogen levels,blood lipids,liver function level and neonatal outcome of the two groups were measured and analyzed.Results Levels of estradiol-2(E2)and estradiol-3(E3)in observation group were(62.35±13.95)ng/L and(45.48±19.57)ng/L,respectively,and they were(41.66±8.65)ng/L,(28.86±11.19)ng/L in control group,on the difference between the two groups was significant(P<0.05).The levels of total cholesterol,triacylglycerol and low density lipoprotein in observation group were significantly higher than those in control group(P<0.05).High density lipoprotein in observation group was significantly lower than that in control group(P<0.05).Levels of total bile acid,aspartie transaminase,total bilirubin,alanine aminotransferase in observation group were higher than those in control group(P<0.05).Incidence of intrauterine distress,neonatal asphyxia and premature infants and perinatal mortality in ICP patients were 15.00%,13.33%,16.67%,respectively,and they were 2.00%,1.00%,2.00%,respectively,in control group,and the difference was significant(P<0.05);but the perinatal mortality in ICP patients was 1.67%,and 0 in control group,there was no significant difference between the two groups(P>0.05).Conclusions Serum lipids and estrogen levels in ICP patients have obvious abnormal changes.Timely detection of serum lipids and estrogen is conductive to clinical intervention as early as possible and reducing adverse neonatal outcomes.
作者
范月莲
Fan Yuelian(Department of Obstetrics and Gynecology,Shanxi Provincial People's Hospital,Taiyuan 030012 ,China)
出处
《中国实用医刊》
2019年第3期31-33,共3页
Chinese Journal of Practical Medicine
关键词
妊娠期
肝内胆汁淤积症
血脂
雌激素
Pregnancy
Intrahepatic cholestasis
Blood lipids
Estrogen
