摘要
目的 观察以时辰给药法进行新辅助化疗与常规新辅助化疗治疗宫颈癌的近期疗效及毒副作用。方法 时辰新辅助化疗组用药为顺铂 (DDP) ,给药时间为 4pm ;氟脲嘧啶 (5 -Fu) ,给药时间为 0am～ 8am ,在3am～ 5am给予药物总量的 75 %。常规新辅助化疗组所用药物及剂量同时辰新辅助化疗组 ,用药时间安排在正常上班时间的 8am～ 5pm。完成 2个疗程化疗后根据患者检查情况选择手术治疗或根治性放疗 ,评价化疗近期的毒副反应及化疗的近期疗效。结果 时辰新辅助化疗组总有效率与常规新辅助化疗组相比为88 9%VS78 1% (p <0 0 5 ) ,差异具有显著性。化疗后选择单纯手术治疗的治疗方式 ,时辰新辅助化疗组与常规新辅助化疗组相比为 5 0 %VS 37 5 % (p <0 0 5 ) ,时辰新辅助化疗组Ⅲ、Ⅳ度白细胞下降显著低于常规新辅助化疗组 ,其余化疗近期毒副反应两组间无显著差异。结论 在宫颈癌的新辅助化疗中采用PF方案时 ,时辰新辅助化疗组的近期疗效高于常规新辅助化疗组 ,两组的化疗近期毒副反应基本相同 。
Objective To observe the short term efficacy and toxic side effects of the neoadjuvant chemotherapy with cisplatin and fluorouracil in locally advanced cervical cancer by a chronomodulated in fusion and a routine method.Methods Cisplatin was administered at 4 pm with fluorouracil from 0 am to 8am,75%was given between 3 am and 5 am in group A.In group B the same doses of cisplatin and fluorouracil were given in daily working time from 8 am to 5 pm by the routine infusion method.The short term toxic side effects and the short term efficacy were evaluated after completed two cycles and then followed by radical hysterectomy or radiotherapy.Results Total response rate was higher in group A than that in group B(P<0 05).Grade 3 or 4 toxic side effects were mainly the decrease of white blood corpuscles which were remarkably lower in group A than in group B(P<0 05).Conclusion The short term efficacy of PF regimen in the neoadjuvant chemotherapy in locally advanced cervical cancer is apparently higher in the chronotherapy group A than in the routine group B.However,there is no difference in the short term toxic side effects between these two groups.The chonomdulated infusion methods is useful in the neoadjuvent chemotherapy in locally advanced cervical cancer.
出处
《现代肿瘤医学》
CAS
2003年第3期186-188,共3页
Journal of Modern Oncology
