摘要
目的探讨时辰化疗与常规化疗在卵巢癌中临床应用,观察两种治疗的近期疗效及毒副作用。方法时辰化疗组(A组)用药为环磷酰胺(CTX)600mg/m210am给药,顺铂(DDP)100mg/(m2·d),给药时间16:00～18:00。常规化疗组(B组)所用药物及剂量同时辰化疗组,用药时间安排在正常上班时间8:00～17:00,完成2个疗程化疗后评价化疗近期的毒副反应及近期疗效。结果时辰化疗组总有效率与常规化疗组相比为72.8%VS66.3%(P<0.05),差异具有显著性。时辰化疗组的毒副反应对白细胞下降、肾脏毒性明显低于常规化疗组(P<0.05),其余化疗近期毒副反应两组比较显示时辰化疗组低于常规化疗组,但无显著差异。结论时辰化疗组在治疗卵巢癌中较常规化疗组能显著提高疗效,且毒副反应小,减少耐药性。
Objective To explore the chrono-chemotherapy and routine chemotherapy in the treatment of ovarian cancer,we aim to evaluate the short term toxic side effects and efficacy. Methods In chrono-chemotherapy group（ groupA） ,cyclophosphamide （ CTX） 600 mg/m2 was administered at 10 am with cisplatin（ DDP） 100 mg/m2 /d from 4 pm to 6pm. In routine chemotherapy group（ groupB ） the same doses of CTX and DDP were given in daily working time from 8 am to 5 pm by the routine infusion method. The short term toxic side effects and efficacy were evaluated after completing two cycles of chemotherapy. Results Total response rate was higher in group A than that in group B（ 72. 8% vs66. 3% ,respectively） （ P 0. 05） were considered statistically significant. Chrono-chemotherapy were mainly the decrease of white blood corpuscles and toxic properties of kidney which were remarkably lower in group A than in group B （ P 0. 05） . And there were no statistical differences in the other toxic sides effects. Conclusion The short term efficacy of PF regimen in the neoadjuvant chemotherapy in locally advanced ovarian cancer is apparently higher in the chronotherapy group than in that the routine group .
出处
《中国现代药物应用》
2010年第21期9-10,共2页
Chinese Journal of Modern Drug Application
基金
深圳市宝安区课题立项(项目编号:2009427)
关键词
时间药理学
昼夜节律
卵巢癌
时辰化疗
Chronopharmacology
Circadian rhythms
Ovarian cancer
Chrono-chemotherapy
