摘要
目的 探讨脑血管病危险因素对脑梗死后继发认知障碍的作用及影响。方法 应用改良的HDS R量表 ,对 10 1例脑梗死患者在急性期 ( 3周 )和康复期 ( 6个月 )时进行认知测评和神经功能缺损评分。用既往史和伴发病调查表收集脑血管病危险因素相关资料。对观察项目结果和认知动态变化结果进行单因素、Logistic回归分析和相关分析。结果 急性期认知障碍组 ( 65例 )与认知正常组 ( 3 6例 )年龄、性别、伴发疾病总分差异有显著性 (P <0 .0 1)。康复期认知障碍组 ( 5 3例 )与认知正常组 ( 4 8例 )年龄、伴发疾病总分和既往史总分差异有显著性 (P <0 .0 1)。相关分析提示认知障碍的发生与发热和长期饮酒显著相关 ,与肥胖、心脏病、高血压、糖尿病、高血脂、呼吸道感染、吸烟、体育活动和TIA史无显著相关。Logistic多元回归分析急性期认知障碍的危险因素是年龄 (P =0 .0 2 9)和性别 (P =0 .0 15 )。Logistic多元回归分析康复期认知障碍的危险因素是年龄 (P =0 .0 0 1)。结论 脑血管病危险因素对脑梗死后认知障碍呈共同叠加影响。急性期并发症、发热与脑梗死后认知障碍相关 ,长期饮酒影响脑梗死后认知功能 ,高龄是脑梗死后认知障碍的独立危险因素。
Objective To study the correlation between risk factors of CVD and cognitive deficit associated with cerebral infarction. Methods Cognitive function was tested in 101 cases of cerebral infarction using HDS-R at the end of 3 weeks and 6 months after onset of the stroke. Meanwhile, the data of risk factors and relative information of cerebral vascular disease were collected by using the scale of complications and inquiring the past history. The risk factors of CVD, such as neurological deficit, diabetes, hypertension, obesity, fever, heart diseases, smoking, overdrinking were compared between the cognitive deficit group and non-cognitive deficit group. Logistic regression analysis was adopted for data analysis. Results Of the 101 cases , 65 had cognitive deficit at the end of 3 weeks and 53 at the end of 6 months after onset of stroke. Age and score of scale of complications between cognitive deficit group and non cognitive deficit group were significantly different(P<0.01). Logistic regression analysis showed that age (P=0.029)and gender (P=0.015) were significantly different at the end of 3 weeks. Age was the only significant influencing factor at the end of 6 months (P=0.001). Relative analysis showed that fever and overdrinking were correlated significantly with the incidence of cognitive deficit. Other risk factors of CVD, such as hypertension, diabetes, obesity, hyperlipemia, physical activities and smoking had no significant influence on the incidence of TIA. Conclusion The risk factors of cerebral vascular diseases have additive influence on cognitive deficit after cerebral infarction. Fever and chronic drinking is correlated with the incidence of cognitive deficit. Age is an independent risk factor of cognitive deficit associated with cerebral infarction.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2003年第7期422-425,共4页
Chinese Journal of Physical Medicine and Rehabilitation
