摘要
目的不同条件下罗红霉素包衣缓释微丸的体外释放。方法用释放度测定法考察影响药物释放的各种因素。结果致孔剂用量、包衣增重等是影响药物释放的关键因素。以甲基丙烯酸树脂Eudragit NE30D为包衣材料,温度为21～28℃,包衣增重5%(w),致孔剂用量为乳糖占包衣增重10%,熟化24 h,所制微丸具有明显的缓释特性。结论以甲基丙烯酸树脂Eudragit NE30D作为包衣材料所得缓释微丸符合24 h缓释要求。
objective To evaluate the in vitro release of roxithromycin from sustained-released pellets.Methods In vitro release was evaluated by the method for release determination described in the Ch.P.2000 Ed. Result Amount of lactose in coating material,the coating thickness,etc,had significantly effects on the release rate. The profiles of sustained-release were obtained at the following condition: Eudragit NE30D as the coating material,coating temperature of 21～28 ℃,amount of lactose was 100 g·L-1in coating material,increased weight on the pellets by coating material was 50g·L-1. Conclusion The prepared pellets met the release standard of 24 h sustained release formulation.
出处
《中国药剂学杂志（网络版）》
2005年第1期1-8,共8页
Chinese Journal of Pharmaceutics：Online Edition
关键词
药剂学
包衣缓释微丸
挤出滚圆法
罗红霉素
水分散体
甲基丙烯酸树脂
pharmaceutics
coated sustained-release pellets
extrusion-spheronization method
roxithromycin
aqueous dispersion
Eudragit NE30D
