摘要
采用挤出滚圆法制备含药微丸,药物以固体分散体的形式存在微丸中,流化床进行肠溶包衣,制得替米考星肠溶微丸。通过不同的工艺处方筛选,考察其理化性质及体外释放特性。分别采用紫外分光光度计测定替米考星的含量,电子显微镜、红外分光光度法和差示扫描量热法确证微丸的特性。结果显示,微晶纤维素在一定程度上对微丸骨架的成型有影响,而包衣的厚度影响微丸的体外释放行为。释放度实验表明替米考星肠溶微丸能达到肠溶制剂的效果。
The tilmicosin contained pellet core was prepared using extrusion spheronization method followed by the enteric coating with enteric coated powder using the technology of fluidized bed. The physicochemical properties and in vitro release characteristics was investigated by different screening of prescription and technology. The content of tilmicosin were determined by using UV spectrophotometer, while properties of pellets was confirmed by electron microscopy, infrared spectrophotometry and differential scanning calorimetry. The results showed that microcrystalline cellulose, to a certain extent, had effect on forming the pellets skeleton, while the coating thickness influencing the pellets in vitro release. The solid dispersion of tilmicosin was formed when tilmicosin enteric coated pellets were prepared by extrusion spheronization. The experiments of drug release showed that tilmicosin enteric coated pellets met enteric efficiency.
出处
《中国兽药杂志》
2014年第2期34-38,共5页
Chinese Journal of Veterinary Drug
关键词
替米考星
肠溶微丸
释放度
固体分散体
tilmicosin
enteric coated pellets
drug release
solid dispersion
