摘要
目的探讨克罗米芬(CC)与来曲唑(LE)对多囊卵巢综合征(PCOS)患者促排卵效果及其妊娠的影响。方法选取2013年12月—2015年12月大邑县妇幼保健院收治的PCOS患者64例,随机将患者分为CC组(33例)和LE组(31例)。CC组口服CC治疗,LE组口服LE治疗,比较两组患者促排卵情况(包括完成的促排卵周期、有排卵周期、子宫内膜厚度、成熟卵泡数、最大卵泡直径)、治疗后临床妊娠情况(包括正常妊娠、流产以及多胎妊娠)及临床妊娠者平均用药周期。结果 CC组患者排卵周期高于LE组,差异有统计学意义(P<0.05);CC组患者人绒毛膜促性腺激素(HCG)日监测到的成熟卵泡个数多于LE组,但LE组患者子宫内膜厚度厚于CC组,差异有统计学意义(P<0.05)。两组正常妊娠率比较,差异无统计学意义(P>0.05);两组流产和多胎妊娠率比较,差异无统计学意义(P>0.05);CC组临床妊娠者治疗周期短于LE组,差异有统计学意义(P<0.05)。结论 CC与LE对PCOS患者促排卵效果和妊娠情况各有特点,但整体上疗效较为相似。
Objective To investigate the ovulation induction effect and the impact on pregnancy of clomiphene( CC)and letrozole( LE) in patients with polycystic ovarian syndrome( PCOS). Methods A total of 64 PCOS patients from December 2013 to December 2015 in Maternal and Child Health Care Hospital of Dayi County were selected and randomly divided into CC group( 33 cases) and LE group( 31 cases). CC group were treated with oral CC,LE group were treated with LE,ovulation situation( including the cycle of ovulation,the ovulation,endometrial thickness,the number of mature follicles,maximum follicle diameter),clinical pregnancy after treatment( including normal pregnancy,abortion and multiple pregnancy) and clinical pregnancy average treatment period between the two groups were compared. Results Ovulation cycle of CC group was higher than the LE group,the difference was statistically significant( P < 0. 05); in CC group,HCG to monitor the number of mature follicles were more than LE group,but endometrial thickness of LE group was bigger than the CC group,the differences were statistically significant( P < 0. 05). Normal pregnancy rate between the two groups showed no significant differences( P >0. 05),abortion and multiple pregnancy rate comparison between the two groups showed no significant differences( P > 0. 05);clinical pregnancy treatment cycle of CC group was shorter than that of LE group,the difference was statistically significant( P< 0. 05). Conclusion CC and LE in PCOS patients with ovulation induction effect and the characteristics of each pregnancy,but the overall effect is more similar.
出处
《临床合理用药杂志》
2016年第30期38-39,51,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
多囊卵巢综合征
氯米芬
排卵诱导
Polycystic ovary syndrome
Clomiphene
Ovulation induction
