摘要
目的探讨微刺激促排卵方案在卵巢功能正常的患者行体外受精-胚胎移植(IVF-ET)助孕治疗中的应用效果。方法选择首次行IVF-ET助孕治疗的卵巢功能正常的不孕患者79例,年龄均<35岁,分为研究组共35例(35个周期)及对照组共44例(44个周期),研究组使用微刺激方案促排卵,对照组采用标准长方案促排卵治疗。比较两组的胚胎移植情况、激素水平及临床结局等。结果研究组中,有1例因雌二醇(E2)水平下降和黄体酮水平上升取消用药周期,1例因胚胎质量差取消移植,1例出现黄体生成素(LH)峰而排卵,共32个周期进行胚胎移植,获卵数(8.35±3.35)枚,临床妊娠13例,周期临床妊娠率为40.62%(13/32);对照组无出现LH峰、E2水平下降和黄体酮水平上升等情况,共41个周期行胚胎移植,获卵数(14.2±6.9)枚,临床妊娠21例,周期临床妊娠率51.21%(21/41)。与对照组比较,研究组人绒毛膜促性腺激素(HCG)使用日的LH及黄体酮水平较高、E2水平较低、子宫内膜厚度较薄,使用尿促性腺激素的时间及剂量、获卵数、M2卵、移植胚胎数和冻胚数均较少(P均<0.05);两组受精率、优胚率、妊娠率、胚胎种植率、累积妊娠率、多胎率、流产率、宫外孕率和卵巢过度刺激综合征发生率比较,差异均无统计学意义(P>0.05)。结论对于卵巢功能正常的患者应用微刺激方案行IVF-ET助孕治疗可以取得一定的临床效果,但不如标准长促排卵方案稳定。
Objective To explore the application efficacy of mild stimulation protocol during in vitro fertilization and embryo transfer （IVF-ET） in patients with normal ovarian function. Methods Seventy-nine infertile patients （younger than 35 years old ） with normal ovarian function received IVF-ET treatment for the first time and were selected in this study. The patients were divided into study group （n = 35 ,consisted of 35 cycles） and control group（ n = 44, consisted of 44 cycles） . Mild stimulation protocol and standard long protocol for stimulation were conducted in the study group and the control group respectively. The embryo transplantation, hormone levels and clinical outcomes were compared between the two groups. Results In the study group,medication cycle was cancelled in one case due to the decreasing estradiol（ E2 ） level and increasing progesterone level, transplantation was cancelled in one case due to the poor quality of the embryo, and ovulation occurred in one case due to the onset of luteotropic hormone（LH） peak, thus embryo transplantation was conducted in 32 cycles. The number of retrieved ooeytcs was （8.35 ± 3.35 ） ,and clinical pregnancy was performed in 13 cases and the clinical pregnancy rate of cycle was 40.62% （13/32） in the study group. In the control group, no LH peak, decreasing E2 level and increasing progesterone level occurred in any cases,and embryo transplantation was conducted in 41 cycles. The number of retrieved oocytes was （14.2 ± 6.9） , and clinical pregnancy was performed in 21 eases and the clinical pregnancy rate of cycle was 51.21% （21/41 ） in the control group. Compared to the control group, LH and progesterone levels were higher, E2 level was lower and endometrial thickness was thinner on the day of using human chorionic gonadotropin（HCG） ,the usage duration and dosage of menotropins,the numbers of retrieved oocytes and M2 oocytes, transferring embryos and eryopreserved embryos were less in the study group （ all P 〈 0.05 ）. Th
出处
《广西医学》
CAS
2016年第11期1564-1567,共4页
Guangxi Medical Journal
基金
广西区计划生育委员会科研课题(桂人口计生研1003)
关键词
体外受精-胚胎移植
微刺激
长方案
促排卵
临床结局
In vitro fertilization and embryo transfer, Mild stimulation, Long protocol, Hyperstlmulation, Clinical outcome
