摘要
以西咪替丁为印迹分子 ,2 丙烯酰胺 - 2 甲基丙磺酸 (AMPS)为功能单体 ,三羟甲基丙烷三甲基丙烯酸甲酯 (TRIM)为交联剂 ,采用悬浮聚合法制备得到了平均粒径在 6 0～ 310 μm之间的分子印迹聚合物微球(MIPMS) ,将所得的MIPMS用作固相萃取剂 (SPE)的测试结果表明 ,该MIPMS对西咪替丁有较好的特异选择性能 ,当以苯丙氨酸为竞争分子时 ,分离因子可达 1.75 ,且该MIPMS呈现出较好的再生性。
The molecularly imprinted polymeric microspheres (MIPMS) was prepared via suspension polymerization, using cimetidine as printing molecule, 2-acrylamido-2-methylpropanesulfonic acid (AMPS) as functional monomer and trimethylolpropane trimethacrylate.(TRIM) as cross-linker. The major factors that influence the sizes and size distribution of the MIPMS were discussed, and the molecule selecting property of the MIPMS were evaluated by using them as solid-phase extraction sorbents. The results showed that MIPMS between 60 similar to 310 mum in average diameter could be prepared by varying the dosage of dispersant, hydroxy ethylic cellulose, using proper amount of toluene as dilute as well. The cimetidine imprinted MIPMS had a considerable property of molecule selecting to cimetidine with the separate factor up to 1.75 when L-Phenylalanine was used as competitive molecule, and the MIPMS also exhibited a good regeneration property. On the other hand the control polymers had no molecule selecting property at all, which well confirms the effect of imprinting.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
2003年第6期655-658,共4页
Chinese Journal of Analytical Chemistry
基金
国家自然科学基金资助课题 (No .2 990 60 0 8)
