摘要
目的 :研究丹芝舒心胶囊的制备方法及质控标准 ,并观察其临床疗效。方法 :对处方中的丹参、元胡、冰片进行薄层色谱鉴别 ,测定醇溶性浸出物的含量 ,并进行动物急性毒性试验和临床观察。结果 :层析分离清晰 ,空白无干扰 ,重现性好。动物试验LD50>12 08g生药/kg。临床总有效率为86 80%。结论 :组方合理 ,工艺可行 ,质控方法可靠 ,无毒性 ;
OBJECTIVE:To prepare Danzhisuxin capsule,establish the standard of quality control and to observe its cliniˉcal effect.METHODS:Dadix salviae miltiorrhizae,Rhizoma corydalis and Borneolum sytheticum in Danzhisuxin capsule were identified by TLC.The amount of alcohol extract was measured.Animal acute toxic test was performed and clinical effects were observed.RESULTS:Checking with TLC was simple and rapid.This method was feasible and had a good repeatability.In anˉimal test,LD 50 >12.08g herbs/kg.The overall effective rate for coronary heart disease was86.8%.CONCLUSION:Danzhisuxin capsule is appropriate in formulation and feasible in preparation technique.The method of quality control is reliˉable.No toxic reactions were found and the clinical effect was satisfactory.
出处
《中国药房》
CAS
CSCD
2003年第6期339-341,共3页
China Pharmacy
