摘要
心喘灵(XC-1)抑制异丙肾上腺素加快大鼠有心房自发性频率的作用,能使量—效反应曲线右移,XC-1也能抑制大鼠主动脉螺旋条由高K^+去极化和去甲肾上腺素诱发收缩张力增加的作用。XC-1与沛心达(perhexiline)作用相似,都有钙拮抗作用,能拮抗受体控制性钙通道(ROC)和电位依赖性钙通道(PDC);并证明XC-1与沛心达对内Ca^(2+)释放和外源性Ca^(2+)诱发主动脉螺旋条的收缩都有抑制作用。
Xinchuanling (XC-1) is a new synthetic drug by Henan research institute of medicine industry .This paper will report the calcium antagonistic action of XC-1.×C-1 ( 2×10-6 ~2 ×10-5g/ml ) inhibited the speedup effect of isoprenaliue on spontaneous beating in the isolated atria of rats with the dose-effect relation being shifted to the right and the maxium effect being inhibited.×C-1(2×10-6) had inhibitory effects on the contractile force of the aortic strips induced by KCl(60mmol/L) and noradrenaline (30nmol/L). It suggested that the mode of action of XC-1 ( 2×10-6g/ml)to aortic strips was blocked the receptor operated calcium channel and potential dependent calcium channel.In Ca2+ free Krebs solution,XC-1( 2×10-6g/ml ) and perhexiline ( 37.5μmol/L ) depressed the contractile force induced by noradrenaline(30nmol/L ) and calcium (2.25mmol/L)in the isolated aortic strips of rat. It suggested that XC-1 and perhexiline were not only to inhibit the release of intracellular Ca2+ but also to brock the influx of extracellular Ca2 + .
出处
《基础医学与临床》
CSCD
1992年第1期29-31,22,共4页
Basic and Clinical Medicine
关键词
心喘灵
受体控制性
钙通道
xinchuanling XC-1 perhexiline aortic strips potential dependent calcium channel (PDC )receptor operated calcium channel(ROC)
