摘要
三七叶总甙（Ｔｏｔａｌｓａｐｏｎｉｎｅｓｏｆ Ｌｅａｆ ｏｆ ｐａｆｌａｘｎｏｔｏｇｉｎｓｅｎｇ，ｐＮＬＴＳ）０．５～１ｍｇ／Ｌ抑制异丙肾上腺素加快豚鼠右心房自发频率的作用，能使量效反应曲线右移。ｐＮＬＴＳ１ｍｇ／Ｌ也能抑制大鼠主动脉螺旋来由高Ｋ＋去极化和去甲肾上腺素３０ｎｍｏｌ／Ｌ诱发收缩张力增加的作用。ｐＮＬＴＳＩｍｇ／Ｌ与哌克昔林３７．５ｕｍｏｌ／Ｌ作用相似，都有拮抗作用，能拮抗受体控制性钙通道（ＲＯＣ）和电位依赖性钙通道（ＰＤＣ），并证明ＰＮＬＴＳ与派克昔林对内Ｃａ２＋，释放和外Ｃａ２＋内流诱发主动脉螺旋条的收缩都有抑制作用。
Total saponins of leaf of panax notoginseng (PNLTSj 0.5 and lmg/L inhibited thespeedup effect of isoprenaline on spontaneous beating in the isolated guinea pig atria; the dose-effectrelationship shifted to the right and the maximum effect was inhibited.PNLTS 1mg/L had an inhibitory effect on the contractile force of the aortip strips induced by KCI60mmol/L and nomdrenaline 30runol/L . It implied that the mode of action of PNLTS 1mg/L on aorticstrips was to block the receptor-operated calcium channel and potential-dependent calcium channel .In Ca2+ free Kreb's solution , PNLTS 1mg/L and perhexiline 37.5Pmol/L depressed the contractileforee aortic of the rat isolated aortic strips induced by noradreanaline 30nmol/L and calcium 2.25mmol/L. The results suggested that PNL TS and perhexiline not only inhibited the release of ihtmcellularCa2+ but also blocked the influx of extraellular Ca2+.
出处
《基础医学与临床》
CSCD
1999年第2期81-84,共4页
Basic and Clinical Medicine
基金
国家自然科学基金
关键词
三七叶总甙
抗心律失常
ROC
PDC
右心房
total saponines of leaf of panax notoginseng (PNLTS) Potential-dependent calcium channel (PDC)receptor-operated calcium channel (ROC) aortic strips right auricle
