摘要
苦参总碱（Tital Alkaloid of Sophora Flavescens,TASF）20mg/kg,40mg/kg能明显对抗鸟头碱20ug/kg,BaCl2 2mg/kg和结扎左冠状动脉前降支诱发大鼠的室性心律失常.TASF也能明显对抗CaCl2-Ach（CaCl20.6％+Ach 0.0025％）混合液10ml/kg诱发小鼠心房纤颤或扑动.大鼠心电图（ECG）试验证明TASF有负性频率作用,负性传导作用.这些作用可能是TASF抗心律失常作用的药理学基础.
Total alkaloid of sophora flavescens (TASF) 20 mg/kg and 40 mg/kg could inhibit markedly the ventricular arrhythmias induced by aconitine 20ug/kg or BaCl2 2 mg/kg or coronary ligation in rats. It also obiously reduced the incidence of atrium fibrillation produced by CaCl2-Ach (CaCl2 0.6% + Ach 0.002 5%) 10 ml/kg in mice. These actions similar to Quinidine. The ECG of rats was significantly. P-R changed after i. v of TASF 20 mg/kg. TASF slows the hearts rate and prolongs the P-R and Q-T intervals.
出处
《大连大学学报》
2002年第4期108-110,共3页
Journal of Dalian University
