摘要
目的探究参苓抗癌饮经验方联合化疗对结直肠癌患者术后营养状况、免疫功能、炎症因子及生活质量的影响。方法选择我院收治的74例结直肠癌术后患者,随机分为对照组和观察组,各37例。对照组患者术后给予西妥昔单抗联合XELOX化疗方案;观察组患者在对照组基础上加用参苓抗癌饮经验方,21 d为1个周期,共治疗4个周期。检测术后1 d、7 d患者的营养学指标、免疫功能指标,以及血清炎性因子TNF-α、hs-CRP、IL-1β、MCP-1水平,采用癌症患者生活质量核心问卷(QLQ-C30)评价患者的生活质量,记录两组患者术后毒副反应发生情况。结果术后1 d,两组患者的营养指标、免疫功能指标、血清炎性因子水平、生活质量评分均无显著差异(P>0.05);术后7 d,观察组患者的营养指标Alb、RBC、Hb、TRF、PA水平明显高于对照组(P<0.05);免疫功能指标CD4^+、CD4^+/CD8^+、IgA、IgG、IgM水平明显高于对照组,CD8^+水平明显低于对照组(P<0.05);血清TNF-α、hs-CRP、IL-1β、MCP-1水平明显低于对照组(P<0.05);生活质量评分显著高于对照组(P<0.05)。观察组患者的毒副反应发生率(18.9%)显著低于对照组(40.5%)(P<0.05)。结论参苓抗癌饮联合化疗可明显改善结直肠癌术后患者的营养状态,提高免疫功能,抑制炎性反应,提高生存质量,减轻化疗毒副反应。
Objective To explore the effect of Shenling Kang'ai decoction combined with chemotherapy on nutritional status,immune function,inflammatory factors and quality of life of patients with colorectal cancer after operation.Methods The 74 cases of patients with colorectal cancer treated in our hospital were randomly divided into the control group and the observation group,respectively 37 cases.Patients in the control group received XELOX combined with cetuximab after surgery.The patients in the observation group were added with the self-made Shenling Kang'ai decoction on the basis of treatment in control group.The Shenling Kang'ai decoction was oral administrated,repeated every 21 days for 4 cycles.Detect the changes of the nutritional indicators and immune function indicators at 1d and 7d after surgery,and the serum levels of inflammatory factors TNF-α,hs-CRP,IL-1βand MCP-1.Evaluate the patients'life quality using the core QLQ-C30 questionnaire for cancer patients,and record the toxic and side effects of the two groups of patients after surgery.Results There were no significant differences in nutrition index,immune function index,serum factor level and life quality between the two groups at 1 d after surgery(P>0.05).At 7 d after surgery,the levels of Alb,RBC,Hb,TRF,PA and other indicators in the observation group were significantly higher than those of the control group(P<0.05).The levels of immune function indexes including CD4+,CD4+/CD8+,IgA,IgG and IgM of the observation group were significantly higher than those of the control group,while the levels of CD8+were significantly lower than those of the control group(P<0.05).The serum levels of TNF-α,hs-CRP,IL-1βand MCP-1 were significantly lower than those of the control group(P<0.05).The scores of emotional function,somatic function,cognitive function,role function and social function were significantly higher than those of the control group(P<0.05).The incidence of adverse reactions of the observation group(18.9%)was significantly lower than that of the control
作者
武青生
赵刚
穆元忠
晋国权
WU Qingsheng;ZHAO Gang;MU Yuanzhong;JIN Guoquan(General Surgery Department of the Fifth People’s Hospital of Qinghai Province,Xining,Qinghai,810000,China)
出处
《肿瘤药学》
CAS
2019年第1期125-129,共5页
Anti-Tumor Pharmacy
基金
国家自然科学基金资助项目(81473465)
关键词
结直肠癌
自拟参苓抗癌饮经验方
西妥昔单抗
免疫功能
炎性因子水平
Colorectal cancer
Self-made Shenling Kang'ai Decoction
Cetuximab
Immune function
Levels of inflammatory factors
