摘要
目的:研究膳食纤维肠内营养对结直肠癌术后炎症反应、抗肿瘤免疫应答的影响。方法:选择2015年3月~2017年8月在四川大学华西医院接受结直肠癌根治术的162例患者作为研究对象,随机分为接受膳食纤维肠内营养干预的膳食纤维组以及接受常规营养干预的对照组。手术前及手术后首次排便时,测定肠道菌群的数目;手术前及手术后3d、手术后5d时,测定炎症反应指标及免疫应答指标。结果:手术后首次排便时,两组患者粪便中双歧杆菌、乳酸菌、大肠杆菌、肠球菌的含量均低于手术前,且膳食纤维组患者粪便中双歧杆菌、乳酸菌的含量高于对照组,大肠杆菌、肠球菌的含量低于对照组;手术后3d、手术后5d时,两组患者血清中核因子-κB(NF-κB)、白介素(IL)-1、肿瘤坏死因子-α(TNF-α)、IL-8的含量以及外周血中Treg、Th17、Th22、转化生长因子-β(TGF-β)、IL-17、IL-22的含量均显著高于手术前,且膳食纤维组患者血清中NF-κB、IL-1、TNF-α、IL-8的含量以及外周血中Treg、Th17、Th22、TGF-β、IL-17、IL-22的含量均低于对照组。差异均有统计学意义(P<0.05)。结论:结直肠癌术后膳食纤维肠内营养干预能够抑制炎症反应、改善抗肿瘤免疫应答。
Objective:To study the effect of dietary fiber enteral nutrition on inflammatory response and anti-tumor immune response after colorectal cancer surgery.Methods:162 patients who underwent radical operation for colorectal cancer in West China Hospital,Sichuan University between March 2015 and August 2017 were selected as the research subjects and randomly divided into the dietary fiber group who accepted dietary fiber enteral nutrition intervention and the control group who accepted conventional nutrition intervention.The number of intestinal flora was determined before surgery and at the first defecation after surgery;the inflammatory response indexes and immune response indexes were measured before surgery as well as3 days and 5 days after surgery.Results:At the first defecation after surgery,the bifidobacteria,lactobacillus,Escherichia coli and enterococcus contents in the feces of both groups were lower than those before surgery,and the bifidobacterium and lactobacillus contents in feces of dietary fiber group were higher than those of control group whereas Escherichia coli and enterococcus contents were lower than those of control group;3 days and 5 days after surgery,NF-κB,IL-1,TNF-αand IL-8 contents in serum as well as Treg,Th17,Th22,TGF-β,IL-17 and IL-22 contents in peripheral blood of both groups of patients were significantly higher than those before surgery,and NF-κB,IL-1,TNF-αand IL-8 contents in serum as well as Treg,Th17,Th22,TGF-β,IL-17 and IL-22 contents in peripheral blood of dietary fiber group were lower than those of control group.Conclusion:The dietary fiber enteral nutrition intervention after colorectal cancer surgery can inhibit the inflammatory response and improve the anti-tumor immune response.
出处
《海南医学院学报》
CAS
2018年第4期504-507,511,共5页
Journal of Hainan Medical University
基金
国家自然科学基金(NSFC 81062341)~~
关键词
结直肠癌
膳食纤维
炎症反应
免疫应答
colorectal cancer
dietary fiber
inflammatory response
immune response
