摘要
目的 :探讨NF -κB和P2 7蛋白在原发性胆囊癌中的表达及意义。方法 :采用SP免疫组化法对 4 7例原发性胆囊癌和 2 0例慢性胆囊炎石蜡包埋组织切片进行NF -κB和P2 7染色 ,检测NF -κB和P2 7蛋白表达。结果 :原发性胆囊癌与慢性胆囊炎组织中NF -κB和P2 7蛋白表达的阳性率有显著差异 (P <0 .0 1)。NF -κB在胆囊癌组织中明显高表达 (P <0 .0 5 ) ,P2 7蛋白明显低表达 (P <0 .0 5 ) ;NF -κB ,P2 7蛋白在细胞分化程度、组织学分级间存在显著差异 (P <0 .0 5 )。NF -κB随细胞分化程度的降低、组织学分级的增高明显增高 (P <0 .0 5 ) ,P2 7蛋白则明显降低 (P <0 .0 5 )。结论 :NF -κB的高表达与P2 7蛋白的低表达在原发性胆囊癌的发展过程中起重要作用 ,二者可部分反映原发性胆囊癌的恶性程度及预后。
Objective:To explore the expression of NF-κB and P27 in primary gallbladder carcinoma (PGC) and its relationship with clinic pathologic character.Method:The expression of NF-κB and P27 in 47 cases of PGC and 20 cases of cholecystitis were detected by immunohistochemistry.Results:The postive rate of NF-κB in PGC were significantly higher than cholecystitis ( P <0.01 ),and the postive rate of P27 protein was significantly lower than that of cholecystitis ( P <0.01 ).The expression of NF-κB and P27 were correlated with differentiation of PGC.Conclusion: NF-κB and P27 may play an important role in the pathogensis of PGC and may show vicious level and prognosis of PGC.
出处
《中国现代医学杂志》
CAS
CSCD
2003年第3期43-45,共3页
China Journal of Modern Medicine
