摘要
子宫内膜蜕膜化是决定妊娠能否成功的关键因素之一。磷脂酰肌醇-3-激酶(PI3K)是哺乳动物细胞内基础信号转导通路中的主要细胞因子,在细胞的生长、增殖、凋亡、自噬、血管生成等生理和病理过程中发挥着极其重要的生物学功能。PI3K/蛋白激酶B(PKB/Akt)信号通路在细胞代谢、迁移、分化等方面影响子宫内膜蜕膜化。深入研究PI3K/Akt在子宫内膜蜕膜化中的作用,可为蜕膜化缺陷相关疾病的诊断和治疗提供新思路,对更好地指导临床、提高妊娠成功率具有重要意义。
Endometrial decidualization is one of the key factors determining the success of pregnancy.Phosphatidylinositol-3-kinase(PI3K)is a major cytokine in the basic signaling pathways in mammalian cells,and plays an extremely important biological role in various physiological and pathological processes such as cell growth,proliferation,apoptosis,autophagy and angiogenesis.PI3K/protein kinase B(PKB/Akt)signaling pathway affects endometrial decidualization in various aspects such as cell metabolism,migration and differentiation,etc.In-depth study of the role of PI3K/Akt in endometrial decidualization provides new ideas for the diagnosis and treatment of decidualization-defective related diseases,which is of great significance for better guiding the clinical practice and improving pregnancy success rate.
作者
李新颖
卢利霞
吴天思
杨丹丹
林晓华
LI Xinying;LU Lixia;WU Tiansi;YANG Dandan;LIN Xiaohua(Department of Gynecology,the First Affiliated Hospital of Hebei University of Traditional Chinese Medicine,Shijiazhuang 050011,China;Hebei Provincial Key Laboratory of Integrated Chinese and Western Medicine for Liver and Kidney Disease Research,Shijiazhuang 050091,China;Hebei Province Key Laboratory of Turbiditytoxin Syndrome,Shijiazhuang 050011,China)
出处
《医学综述》
CAS
2024年第3期269-273,278,共6页
Medical Recapitulate
基金
国家自然科学基金(81403428)
河北省中医药管理局科研计划项目(2024019)
河北省政府资助临床医学优秀人才培养项目(ZF2023156)。
