摘要
目的了解2014-2017年涿州市儿童流行性感冒的流行病学特征,为儿童流感的防控工作提供参考。方法采集2014-2017年于涿州市医院就诊的流感样病例(influenza-like illness,ILI)患儿咽拭子标本,应用实时荧光定量逆转录PCR(RT-PCR)对样本进行流感病毒核酸检测和亚型鉴定,分析流感流行趋势和流感病毒的构成情况。结果 2014-2017年共采集ILI咽拭子标本4 816份,检测出流感病毒602例,总体阳性检出率为12.50%。2014-2017年流感病毒阳性率分别为17.34%、14.63%、11.06%、7.24%,呈现递减趋势(P for trend <0.05)。2014-2016年流感病毒以H3N2型为主,2017年流感病毒以B(Yamagata)型和H3N2型为主。2014-2017年流感病毒感染高峰是每年的1-2月份,以H3N2型和B(Yamagata)型流感病毒为主。流感病毒以0~4岁年龄组阳性率最高,占16.01%;以10~14岁年龄组阳性率最低,占8.61%,不同年龄组之间流感病毒阳性率差异及趋势变化均有统计学意义(P <0.05)。结论涿州市2014-2017年流感流行高峰出现在冬春季,0~4岁儿童是主要易感人群,应当加强病原检测,采取有针对性的预防及治疗措施。
Objective To understand the epidemiological characteristics of influenza viruses infection among children in Zhuozhou City from 2014 to 2017,and provide evidence for the prevention and control of influenza among children.Methods Pharyngeal swab specimens of children with influenza-like illness(ILI)in Zhuozhou Hospital from 2014 to 2017 were collected.Real-time fluorescent quantitative reverse transcription polymerase chain reaction(RT-PCR)was used to detect the nucleic acid of influenza virus and identify its subtypes.The influenza epidemic trend and the composition of influenza viruses were analyzed.Results From 2014 to 2017,a total of 4 816 throat swabs of ILI children were collected,and 602 positive specimens were detected,with an overall positive detection rate of 12.50%.From 2014 to 2017,the positive rates of influenza viruses were 17.34%,14.63%,11.06%and 7.24%,respectively,with a decreasing trend(P<0.05).H3 N2 dominated from 2014 to 2016,and B(Yamagata)and H3 N2 dominated in 2017.The positive rate of influenza viruses mostly peaked in January and February from 2014 to 2017.The positive rate of influenza virus was highest in the age group of 0-4 years old(16.01%),while the age group of 10-14 years old had the lowest positive rate(8.61%).There were statistically significant differences in influenza virus positive rates and trend changes among different age groups(P<0.05).Conclusion From 2014 to 2017 in Zhuozhou city,the peak of flu epidemic appears in winter and spring,and children aged 0-4 years old are the main susceptible population.These suggest that we should strengthen the detection of pathogens and take targeted prevention and treatment measures.
作者
李明
马红超
董冰
杨京敏
LI Ming;MA Hongchao;DONG Bing;YANG Jingmin(Department of Pediatrics,Hebei Province Zhuozhou City Hospital,Zhuozhou 072750,Hebei Province,China)
出处
《解放军医学院学报》
CAS
2019年第7期664-667,共4页
Academic Journal of Chinese PLA Medical School
基金
保定市科学计划与发展指导计划项目(17ZF062)~Supported by the Science and Technology Research and Development Project of Baoding(17ZF062)
