摘要
目的观察舒血宁注射液联合前列地尔对糖尿病足溃疡愈合及足背动脉血流动力学指标的影响。方法将84例糖尿病足患者按照随机数字表法分为治疗组和对照组两组,每组各42例。对照组入院后给予临床基础治疗,治疗组在对照组治疗基础上给予舒血宁注射液联合前列地尔治疗。治疗2周后,对比两组中医症状积分(疼痛、麻木、肿胀、跛行)、足部溃疡愈合状况(溃疡面积、创面氧分压、创面pH)、足背动脉血流动力学[足背动脉血流速度、血管内径、阻力指数(RI)、搏动指数(PI)的改善情况,并统计两组临床疗效。结果两组治疗后疼痛、麻木、肿胀、跛行评分均显著降低(均P<0.05),且治疗组治疗后上述症状积分改善状况均显著优于对照组(均P<0.05);两组治疗后溃疡面积、创面pH均显著降低(均P<0.05),创面氧分压均显著升高(均P<0.05),且治疗组治疗后足部创面愈合改善状况均显著优于对照组(均P<0.05);两组治疗后足背血流速度、血管内径、RI及PI水平均显著升高(均P<0.05),且治疗组治疗后足背血流动力学指标改善状况均显著优于对照组(均P<0.05);治疗组治疗后总有效率显著高于对照组(P<0.05)。结论舒血宁注射液联合前列地尔能够快速改善患者临床症状,纠正足背动脉血流动力学异常,促进足部溃疡愈合,两药合用具有协同作用。
Objective To observe the effect of Shuxuening injection combined with alprostadil on healing of diabetic foot ulcers and hemodynamics of dorsal foot artery.Methods 84 cases of patients with diabetic foot were randomly divided into 2 groups,42 cases in each group.Control group was given basic clinical treatment,treatment group was given Shuxuening injection combined with alprostadil on the basis of control group.After 2 weeks of treatment,the improvement of symptom of traditional Chinese Medicine scores(pain,numbness,swelling,limping),foot ulcer healing(ulcer area,wound oxygen pressure,wound pH),the hemodynamics of dorsal foot artery(the blood flow velocity of the dorsal foot artery,the blood vessel diameter,resistance index,pulsation index)of the two groups were statistically analyzed.Results After treatment,the scores of pain,numbness,swelling and claudication were significantly reduced in both groups(P<0.05),and the improvement of the above symptom scores in treatment group was significantly better than those of control group(P<0.05).The area of ulcer and the pH of the wounds in both groups were significantly decreased(P<0.05),and the oxygen partial pressure in the wound was significantly increased(P<0.05).The improvement of foot wound healing in treatment group was significantly better than that of control group(P<0.05);the blood flow velocity of the dorsal foot artery,the blood vessel diameter,the level of RI and PI after treatment in both groups were significantly increased(P<0.05),and the improvement of hemodynamics in treatment group was significantly better than that of control group(P<0.05);the total effective rate of treatment group was significantly higher than that of control group(P<0.05).Conclusion The application of Shuxuening injection combined with alprostadil can quickly improve the clinical symptoms of the patients,correct the hemodynamics of dorsal foot artery and promote the healing of foot ulcers,and the combination of the two drugs has a synergistic effect.
作者
曹洁
魏琦
谢丹
CAO Jie;WEI Qi;XIE Dan(Wuhan Red Cross Hospital,Wuhan 430015)
出处
《湖北中医药大学学报》
2019年第2期84-87,共4页
Journal of Hubei University of Chinese Medicine
基金
武汉市卫生和计划生育委员科研项目(项目编号:JX6B116)
关键词
糖尿病足
溃疡
舒血宁注射液
前列地尔
足背动脉血流动力学
diabetic foot
ulceration
Shuxuening injection
alprostadil
hemodynamics of dorsal foot artery
