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不同剂量六味地黄丸对妊娠期糖尿病模型大鼠脂糖代谢、脂联素及胰岛素抵抗的影响 被引量:9

Effect of Different Dosage of Liuwei Dihuang Pill on Lipid Metabolism, Adiponectin and Insulin Resistance of Gestational Diabetic Rats
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摘要 目的:观察不同剂量六味地黄丸对妊娠期糖尿病(gestational diabetes mellitus,GDM)模型大鼠脂糖代谢、脂联素及胰岛素抵抗的影响。方法:选用SPF级SD大鼠,采用腹腔注射链脲佐菌素的方法制备GDM大鼠模型,选取60只GDM模型大鼠随机分为4组,分别为六味地黄丸低剂量组、六味地黄丸高剂量组、GDM模型组、阳性对照组,每组均15只,另选取正常孕鼠15只作为正常对照组。六味地黄丸低剂量组、六味地黄丸高剂量组大鼠分别给予3 g·kg-1、6 g·kg-1的六味地黄丸混悬液灌胃,每日1次;GDM模型组、正常对照组大鼠则以等体积的生理盐水灌胃,每日1次;阳性对照组大鼠给予盐酸吡格列酮片0.05 g·kg-1灌胃,每日1次。所有大鼠给药8周后停药备用。比较各组大鼠的总胆固醇(total cholesterol,TC)、三酰甘油(triacylglycerol,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterin,LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、空腹血糖、空腹胰岛素、胰岛素抵抗指数(insulin resistance index,HOMA-IR)、脂联素。结果:六味地黄丸高剂量组、六味地黄丸低剂量组的TC、LDL-C高于正常对照组,低于GDM模型组(P<0.05);六味地黄丸高剂量组、六味地黄丸低剂量组的TG低于GDM模型组,HDL-C高于GDM模型组(P<0.05)。六味地黄丸高剂量组、六味地黄丸低剂量组、阳性对照组的空腹血糖、空腹胰岛素、HOMA-IR高于正常对照组、低于GDM模型组(P<0.05),且六味地黄丸高剂量组、阳性对照组的空腹血糖、空腹胰岛素、HOMA-IR低于六味地黄丸低剂量组(P<0.05)。六味地黄丸高剂量组、六味地黄丸低剂量组的血清脂联素水平低于正常对照组,高于GDM模型组(P<0.05),且六味地黄丸高剂量组的血清脂联素水平高于六味地黄丸低剂量组(P<0.05)。结论:六味地黄丸对GDM模型大鼠有一定治疗作用,能够改善大鼠的糖脂代谢和胰岛素抵抗,提高血� Objective:To observe the effects of different doses of Liuwei Dihuang Pill on liposaccharide metabolism,adiponectin and insulin resistance in rats with gestational diabetes mellitus(GDM).Methods:SPF-class SD rats were used to prepare GDM rat model by intraperitoneal injection of streptozotocin.Sixty GDM rats were randomly divided into 4 groups:Liuwei Dihuang Pill Low-dose Group and Liuwei Dihuang Pill.High-dose group,GDM model group and positive control group,15 in each group,and 15 normal pregnant rats were selected as normal control group.Rats with low dose of Liuwei Dihuang Pill and high dose of Liuwei Dihuang Pill were given 3 g·kg-1,6 g·kg-1 Liuwei Dihuang Pill suspension respectively,once a day;GDM model group,normal control group rats were intra-gastrically administrated with an equal volume of normal saline once a day;rats in the positive control group were given pioglitazone hydrochloride tablets at a dose of 0.05 g·kg-1 once a day.All rats were discontinued after 8 weeks of administration.The total cholesterol(TC),triacylglycerol(TG),low density lipoprotein cholesterin(LDL-C),and high density lipoprotein cholesterol were compared between the groups.,HDL-C),fasting blood glucose,fasting insulin,insulin resistance index(HOMA-IR),adiponectin.Results:TC and LDL-C in Liuwei Dihuang Pill High-dose group and Liuwei Dihuang Pill Low-dose group were higher than normal control group,lower than GDM model group(P<0.05);Liuwei Dihuang Pill high dose group and Liuwei Dihuang Pill low dose The TG of the group was lower than that of the GDM model group,and the HDL-C was higher than the GDM model group(P<0.05).Fasting blood glucose,fasting insulin and HOMA-IR in Liuwei Dihuang Pill High-dose group,Liuwei Dihuang Pill Low-dose group and positive control group were higher than normal control group and lower than GDM model group(P<0.05),and Liuwei Dihuang Pill was high dose.Fasting blood glucose,fasting insulin and HOMA-IR were lower in the low-dose group of Liuwei Dihuang Pills(P<0.05).The serum adiponectin level of Li
作者 谭戬浩 李红梅 李辉 戚正涛 赵秋生 TAN Jianhao;LI Hongmei;LI Hui;QI Zhengtao;ZHAO Qiusheng(The Third Affiliated Hospital to Guangzhou University of Chinese Medicine,Guangzhou Guangdong China 510000)
出处 《中医学报》 CAS 2019年第8期1686-1690,共5页 Acta Chinese Medicine
基金 广东省中医药管理局科研项目(20161121)
关键词 妊娠期糖尿病 六味地黄丸 血糖 血脂 脂联素 胰岛素抵抗 大鼠 gestational diabetes Liuwei Dihuang Pill blood glucose blood lipids adiponectin insulin resistance rat
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