摘要
目的:研究恩替卡韦联合苦参碱治疗慢性乙型肝炎的血清炎症细胞因子及肝功能的改善效果。方法:选择符合2015年7月~2016年6月接诊的104例慢性乙型肝炎患者进行研究。按照随机数表法,随机均分为观察组和对照组。所有患者均给予常规保肝治疗,对照组加用恩替卡韦片治疗,观察组在对照组的基础上联合氧化苦参碱注射液治疗,治疗6个月后,比较分析两组患者的血清炎症细胞因子及肝功能水平,并对疗效状况进行分析。结果:治疗前,两组的血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平无显著性差异;治疗后,两组患者的TNF-α、IL-6及IL-8水平均显著降低,且观察组明显低于对照组,两组比较有统计学意义。治疗前,两组患者的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBi L)水平无显著性差异;治疗后,两组患者的ALT、AST、TBi L水平均显著降低,且观察组的ALT、AST、TBi L水平均明显低于对照组。治疗后,观察组的总有效率(92.31%)明显高于对照组(76.92%),两组比较有统计学意义。结论:恩替卡韦联合苦参碱治疗有助于改善慢性乙型肝炎患者血清炎症因子及肝功能状况,提高临床疗效,值得广泛推广应用。
Objective To study the effect of entecavir combined with Matrine on serum inflammatory cytokines and liver function in patients with chronic hepatitis B. Methods 104 patients with chronic hepatitis B who were enrolled in July 2015-June 2016 were selected for the study. According to the random number table method, were randomly divided into observation group and control group. All patients were given routine treatment, the control group was treated with entecavir treatment, observation group in the control group based on the combined oxidation treatment of Matrine Injection, after 6 months of treatment, two groups of patients with serum inflammatory cytokines and liver function, the curative effect were compared and analyzed. Results Before treatment, the level of TNF-α, IL-6 and IL-8 of the two group had no significant difference; after treatment, the TNF-α, IL-6 and IL-8 of the two groups were significantly lower, and the observation group was significantly lower than the control group, the two groups were statistically significant. Before treatment, the level of ALT, AST, TBi L of the two groups had no significant difference; after treatment, the level of ALT, AST, TBi L of the two groups were significantly decreased, and the level of ALT, AST, TBi L of the observation group were significantly lower than control group. After treatment, the total effective rate of the observation group(92.31%) was significantly higher than that of the control group(76.92%), and the difference between the two groups was statistically significant. Conclusion Entecavir combined with Matrine can improve the serum inflammatory factors and liver function in patients with chronic hepatitis B, and improve the clinical efficacy, so it is worth popularizing widely.
出处
《湖南师范大学学报（医学版）》
2018年第2期152-155,共4页
Journal of Hunan Normal University(Medical Sciences)
