摘要
苦参碱能呈剂量相关地抑制乳腺癌MCF-7细胞、Bcap-37细胞、MA737细胞、Walker256细胞、TM40D细胞、4T1细胞、SK-BR-3细胞、MDA-MB-231细胞,以及卵巢癌NuTu19细胞、SKOV3细胞、A21-2细胞、OV2008细胞、HO-8910PM细胞、PA-1细胞、PM-2细胞、3AO细胞、OVCAR3细胞生长并诱导凋亡。苦参碱是这些癌细胞的自噬早期诱导剂,更是自噬晚期抑制剂,通过诱导线粒体凋亡和内质网应激的2个途径引起癌细胞凋亡的,因而能提高癌细胞对放、化疗的敏感性。苦参碱增强机体的免疫调节功能也是其抗癌作用机制的一部分,并能对抗放化疗抑制免疫的毒副作用发生。
Matrine inhibits proliferation and induces apoptosis in association with dosage on mammary cancer MCF-7 cells, Bcap-37 cells, MA737 cells, Walker 256 cells, TM40 D cells, 4 T1 cells, SK-BR-3 cells, MDA-MB-231 cells, and ovarian carcinoma NuTu19 cells, SKOV3 cells, A21-2 cells, OV2008 cells, HO-8910 PM cells, PA-1 cells, PM-2 cells, 3 AO cells, OVCAR3 cells.Matrine is a inducer of early stage of autophagy, and is more a inhibitor of late stage of autophagy. Matrine induces the apoptosis of these cancer cells by two pathways of mitochondria apoptosis and endoplasmic reticulum stress. Matrine enhances sensitivity of cancer cells to radiotherapy and chemotherapy. The immunoenhancement of matrine is its mechanism of antitumor too, and can antagonize occurrence of immunodepression in radiotherapy and chemotherapy.
作者
张明发
王吉星
沈雅琴
ZHANG Mingfa;WANG Jixing;SHEN Yaqin(Shanghai Meiyou Pharmaceutical Co.Ltd.,Shanghai 201204,China;Chinese Academy of Surveillance and Testing(Tianjin)Co.,Ltd.,Tianjin 300300,China)
出处
《药物评价研究》
CAS
2019年第10期2111-2118,共8页
Drug Evaluation Research
关键词
苦参碱
肿瘤
乳腺癌
卵巢癌
matrine
tumor
mammary cancer
ovarian carcinoma
