摘要
苦参碱能防治大鼠胃癌前病变以及乙基硝基亚硝基胍诱发大鼠原发性胃癌,也能防治人胃癌MKN-45细胞、SGC-7901细胞、BG823细胞、人胰腺癌BxPC-3细胞移植瘤在裸鼠或大鼠体内生长。经体外实验发现,苦参碱能浓度相关地抑制人胃癌SGC-7901细胞、MGC803细胞、BGC823细胞、MKN-45细胞、NCI-N87细胞、AGS细胞、人胰腺癌BxPC-3细胞、CFPAC-1细胞、人胆管癌QBC939细胞、人胆囊癌GSC-SD细胞、人食管癌Eca109细胞、Escl细胞的增殖并诱导其凋亡。经体内外实验结果发现,苦参碱能增强化疗药抗人胃癌SGC-7901细胞作用。综述苦参碱对消化系肿瘤临床药理作用的研究文献,并对其研究进展做了分析。
Matrine has the effects in prophylaxis and treatment of gastric precancerous lesion of rat, and rat primary gastric carcinoma induced by N-ethyl-N-nitro-N-nitrosoguanidine, and growth of transplantation tumor of gastric carcinoma MKN-45 cells, SGC-7901 cells, BG823 cells, and pancreatic cancer BxPC-3 cells in rat or nude mice. Matrine inhibits proliferation and induces apoptosis in association with dosage on gastric carcinoma SGC-7901 cells, MGC803 cells, BGC823 cells, MKN-45 cells, NCI-N87 cells, AGS cells, pancreatic cancer BxPC-3 cells, CFPAC-1 cells, cancer of biliary duct QBC939 cells, carcinoma of gallbladder GBC-SD cells, carcinoma of esophagus Eca109 cells, and Escl cells in vitro. Matrine can promote the effects of chemotherapeutics against gastric carcinoma SGC-7901 cells in vivo and in vitro. The literatures on clinical pharmacological effects of matrine on digestive system tumors have been reviewed and their research progress has been also analyzed.
作者
张明发
沈雅琴
ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd.,Shanghai 201204,China)
出处
《抗感染药学》
2020年第1期1-7,共7页
Anti-infection Pharmacy
关键词
苦参碱
胃癌
胰腺癌
胆管癌
胆囊癌
食管癌
研究进展
matrine
gastric carcinoma
pancreatic cancer
cancer of biliary duct
carcinoma of gallbladder
carcinoma of esophagus
research advances
