摘要
苦参碱能抑制增生性瘢痕成纤维细胞增殖和胶原的合成,并诱导凋亡和基质金属蛋白酶的表达,对增生性瘢痕具有防治作用。苦参碱也能抑制皮肤癌细胞增殖并诱导其凋亡,也能抑制表皮角质形成细胞的增殖和黑素的生成。苦参碱对各种免疫性和非免疫性皮肤炎症均有抗炎作用,临床上已被试用于皮炎的治疗。综述苦参碱对皮肤疾病的药理作用及其临床应用近况的文献资料,并对其药理作用做了分析。
Matrine inhibits proliferation and collagen synthesis of hyperplastic scar fibroblasts,and induces apoptosis and expression of matrix metalloproteinase(MMP),and it has the effect of prophylaxis and treatment of hyperplastic scar.Matrine inhibits proliferation and induces apoptosis of skin carcinoma cells,and too inhibits proliferation of epidermic keratinocyte and melanogenesis.Matrine has anti-inflammatory effects against various immune and non-immune dermatitis.In clinic practice matrine has been tried on the treatment of dermatitis.The data of the pharmacological effects of matrine on skin diseases and its clinical medication were reviewed in this article and its the pharmacological action was also analyzed.
作者
张明发
沈雅琴
ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd、Shanghai 201204,China)
出处
《抗感染药学》
2019年第12期2040-2045,共6页
Anti-infection Pharmacy
