摘要
以氯甲酸苯酯和苯胺类化合物为原料,通过酰基化反应生成苯胺基甲酸苯酯类,然后与水合肼经肼解反应生成N-苯基缩氨基脲,最后与苯甲醛反应合成了N-苯基苯甲醛缩氨基脲衍生物。三步反应均在常温条件下完成,反应总收率80%以上,操作简单,适合工业化生产。
Anilinobenzoic acid phenyl esters were synthesized from phenyl chloroformate and aniline compounds.The obtained anilinobenzoic acid phenyl esters reacted with hydrazine hydrate to give N-phenyl semicarbazide.Finally,N-phenyl benzaldehyde semicarbazide derivatives were obtained by the reaction of N-phenyl semicarbazides with benzaldehyde.The results showed that this three-step reaction could performed at room temperature with a total yield of 84.7%.It is easy to operate and suitable for industrial production.
作者
梁明月
谭伟强
吕丽莉
郑纪芳
杨启鹏
LIANG Ming-yue;TAN Wei-qiang;LüLi-li;ZHENG Ji-fang;YANG Qi-peng(Research Center of Environmental Biology and Green Chemistry,School of Environmental and Municipal Engineering,Qingdao Technological University,Qingdao 266033,China)
出处
《精细化工中间体》
CAS
2019年第3期12-15,共4页
Fine Chemical Intermediates
基金
国家自然科学基金资助项目(21506109)
教育部海洋药物重点实验室(中国海洋大学)开放课题(KLMD(OUC)201301)
关键词
N-苯基苯甲醛缩氨基脲
合成
氯甲酸苯酯
N-phenyl-N’-benzaldehyde semicarbazone
synthesis
phenyl chloroformate
