摘要
目的探讨小儿抗生素相关性腹泻(antibiotic-associated diarrhea,AAD)的有效治疗措施以及影响临床疗效的相关因素。方法收集2012-02/2014-02月诊治的93例抗生素相关性腹泻患儿,根据个体情况进行临床治疗,治疗72 h后评估疗效,对疗效影响因素先作单因素分析,然后采用多因素Logistic回归分析影响临床疗效的相关因素。结果单因素分析结果显示应用微生态制剂、微生态制剂的种类、口服补液盐Ⅲ、应用糖皮质激素以及中药复方制剂有可能对疗效产生影响;Logistic回归分析显示,应用微生态制剂、糖皮质激素应用、应用中药复方制剂为疗效的共同影响因素。结论在符合用药适应症的前提下,AAD患儿通过应用微生态制剂、暂停或减少激素应用、应用中药复方制剂有可能提高AAD疗效。
Objective To investigate the effective therapy of children with antibiotic-associated diarrhea(AAD)and investigate factors influencing clinical efficacy.Methods A total of 93 AAD children from February2012 to February2014were given treatment according to the individual clinical situation.Statistical analyses were performed with single factor analysis and logistic regression analysis.Results Factors influencing the clinical responses of therapy were the application of probiotics,the type of probiotics,oral rehydration saltsⅢ,hormone as well as the application of traditional Chinese medicine.Furthermore,the factors influencing the AAD children getting cure was application of probiotics,hormone and Chinese medicine,which were demonstrated by logistic regression analysis.Conclusion Subject to drug indications,the application of probiotics in children with AAD,suspended or reduced hormone application and the application of traditional Chinese medicine may improve the treatment efficacy.
出处
《华南国防医学杂志》
CAS
2015年第2期104-106,共3页
Military Medical Journal of South China
关键词
抗生素相关性腹泻
患儿
治疗措施
影响因素
Antibiotic-associated diarrhea
Children
Therapy
Influencing factors
