摘要
目的观察DNA聚合酶β(DNA polβ)表达对食管癌放化疗疗效的影响。方法 98例食管癌患者根据DNA polβ表达分为阴性单纯放疗组、阴性放化疗组、阳性单纯放疗组、阳性放化疗组4组。各组均进行常规分割放疗,2 Gy/次,5次/周,中位处方剂量60 Gy。2个放化疗组放疗的同时给予顺铂、5-Fu和亚叶酸钙方案化疗,于放疗开始的第1、5周给予。结果阴性单纯放疗组、阴性放化疗组、阳性单纯放疗组、阳性放化疗组的3 a局部控制率分别为54.5%、61.5%、41.7%、53.8%,3 a生存率分为31.8%、38.4%、25.0%、26.9%。结论 DNA polβ表达阴性者放疗联合化疗可改善其生存。
Objective To investigate the relationship between expression of DNA polβ and efficacy of radiotherapy and chemotherapy for esophageal cancer. Methods The 98 patients with esophageal cancer were divided into four groups: the DNA polβ negative radiotherapy group,the DNA polβ negative chemoradiotherapy group,the DNA polβpositive radiotherapy group and the DNA polβ positive chemoradiotherapy group. All the patients received the common radiotherapy,2 Gy each time,5 times per week and the median prescription dose for four groups was both 60 Gy. The cisplatin,5-Fu and calcium folinate regimen was selected for the two chemoradiotherapy group. Results The 3-year local control rates were 54. 5%,61. 5%,41. 7% and 53. 8% respectively in the four groups,and the 3-year survival rates were 31. 8%,38. 4%,25% and 26. 9% respectively in the four groups. Conclusion Chemoradiotherapy can improve the survival rate of patients with DNA polβ negative.
出处
《肿瘤基础与临床》
2016年第3期201-205,共5页
journal of basic and clinical oncology
基金
泰安市科技发展一般计划项目(编号:201440774-43B)
关键词
食管肿瘤
放疗
化疗
DNA聚合酶Β
预后
esophageal neoplasms
radiotherapy
chemotherapy
DNA polβ
prognosis
