摘要
目的探讨术前血浆D-二聚体水平与食管鳞癌患者预后的关系。方法入组经病理确诊的112例食管鳞癌患者,分析其血浆D-二聚体水平与临床病理参数、生存情况的关系。结果术前血浆D-二聚体水平与患者的T分期、N分期及是否复发有关(P<0.05)。血浆D-二聚体水平升高组患者的1 a、3 a生存率分别为76.8%、34.1%,低于D-二聚体正常组的85.5%、52.4%,差异有统计学意义(P均<0.05)。多因素分析显示血浆D-二聚体水平升高是一个不良预后因素(HR:1.679,P<0.05)。结论术前高水平血浆D-二聚体预示食管鳞癌患者较差的预后。
Objective To explore the relationship of preoperative plasma D-dimer level with prognosis of esophageal squamous cell carcinoma. Methods The preoperative plasma D-dimer levels of 112 patients with esophageal squamous cell carcinoma were detected,and the relationships with clinicopathological factors and prognosis were analyzed. Results The preoperative plasma D-dimer level of patients with esophageal squamous cell carcinoma was closely correlated with the T stage,N stage and recurrence( P < 0. 05). The overall 1- and 3-year survival rates of the patients with high plasma D-dimer levels were 76. 8% and 34. 1%,those of the patients with low plasma D-dimer level were 85. 5% and 52. 4%( P < 0. 05). Multivariate analysis showed the plasma D-dimer level was an independent prognostic factor( HR: 1. 679,P < 0. 05). Conclusion High plasma D-dimer level is an independent predictor of poorer overall survival of patients with esophageal squamous cell carcinoma.
出处
《肿瘤基础与临床》
2016年第2期119-121,共3页
journal of basic and clinical oncology
关键词
食管鳞癌
D-二聚体
预后
esophageal squamous cell carcinoma
D-dimer
prognosis
