摘要
目的探讨非小细胞肺癌(NSCLC)患者血浆D-二聚体水平及其与生存期的相关性。方法采用酶联免疫吸附法(ELISA)对55例NSCLC患者及20例健康体检者的血浆D-二聚体进行测定。结果NSCLC患者血浆D-二聚体水平显著高于健康对照组(P<0.01);血浆D-二聚体水平与肺癌的病理类型、TNM分期之间无明显关系,但与其生存期呈显著负相关(r=-0.42,P<0.01)。结论NSCLC患者存在血浆D-二聚体水平增高,且与患者的生存期呈负相关,可作为评估NSCLC预后的重要指标。
Objective To investigate the relationship between the plasma levels of D-dimer and the prognosis in patients with non-small cell lung cancer（NSCLC）. Methods The plasma levels of Ddimer were detected by ELISA method in fifty-five patients with NSCLC and twenty healthy people （control group）. Results The plasma levels of D-dimer in patients with MSCLC were significantly higher than those of control group（P〈0. 01） ,which were not correlated to histological classification, P-TNM stages, but negatively correlated to survival term （ r = - 0.42, P 〈 0. 01 ）. Conclusion Elevation of plasma levels of D-dimer exists in patients with non-small cell lung cancer, which is negatively correlated to the survival term. The plasma level of D-dimer may be taken as a marker of prognosis in patients with NSCLC.
出处
《江苏医药》
CAS
CSCD
北大核心
2007年第12期1207-1208,共2页
Jiangsu Medical Journal
