摘要
目的 为了解Ph染色体阳性 (Ph+ )成人急性B淋巴细胞白血病 (B -ALL)的免疫表型特征。方法 对 78例初治成人B -ALL形态学 (M)免疫学 (I)细胞遗传学 (C)分型结果进行分析。结果 Ph+ 的B -ALL占 2 5例(32 1 % ) ,其中伴髓系抗原 (CD1 3或CD33)表达 (My+ )有 1 4例 (56 0 % ) ,CD1 0和CD1 9均高表达 ,伴淋系抗原 (CD2或CD3或CD7)表达 (Ly+ )有 3例 (1 2 0 % ) ,CD34阳性 1 7例 (68 0 % )。对于Ph染色体阴性 (Ph- )的病例 ,My+ 有 1 2例 ,占 2 2 6 % ,而Ly+ 和CD34阳性的病例分别占 3 8%和 83 0 %。经分析发现 ,Ly+ 和CD34在Ph+ 和Ph+ 的病例中的阳性率差异无显著性。而Ph+ 的成人B -ALL伴My+ 高于Ph- 的成人B -ALL ,且差异具有显著性。结论 成人Ph+ B-ALL通常伴My+ 、CD34表达。Ph+ 与My+ 之间可能具有一定的联系 ,影响成人B
Objective To study the immunophenotypic features of Ph Chromosome positive(Ph +) adult B cell acute lymphoblastic leukemia (B-ALL).Methods Morphologic/cytochemistric,immunophenotypic and cytogenetic(MIC) examinations were preformed in 78 previously untreated adult B-ALL.Results The 25 patients(32 1%) were Ph + among 78 patients.The 14 patients was myeloid associated antigen(CD13,CD33) positive among 25 patients with Ph + B-ALL.The myeloid antigen expression was higher in Ph + cases than Ph - B-ALL.There were no difference in the expression of CD34 or T lymphoid antigen between Ph + and Ph - B-ALL.Conclusion Patients with adult Ph + B-ALL are usually myeloid antigen?CD34 expression.The myloid antigen expression is maybe associated with Ph + in adult B-ALL.
出处
《中国血液流变学杂志》
CAS
2002年第4期272-273,共2页
Chinese Journal of Hemorheology
