摘要
目的 :提高难溶性药物尼莫地平的溶出速率。方法 :选用 PVP-k3 0 和 PEG60 0 0为载体制备了不同晶型尼莫地平固体分散物和机械混合物 ,比较了它们片剂体外的溶出速率。结果 :尼莫地平固体分散物的片剂溶出度高于机械混合物的 ,低熔点机械混合物片剂溶出度高于高熔点的 ,不同晶型尼莫地平 PEG60 0 0固体分散物片剂体外的溶出速率无显著性差异 ,低熔点尼莫地平 PVP-k3 0 固体分散物的片剂的 90 min累积溶出量比高熔点的高。结论 :不同晶型尼莫地平制备成 PVP-k3 0 和 PEG60 0
OBJECTIVE:To enhanced the dissolution rate of nimodipine, a poorly water soluble substance. METHOD:Different polymorphic forms of nimodipine solid dispersion NMDP PVP k 30 and NMDP PEG6000 and physical mixture were prepared. The dissolution rates of NMDP from solid dispersion NMDP PVP k 30 and NMDP PEG6000 and their physical mixture were also compared.RESULTS:The results showed that the dissolution rate of NMDP from the tablets was obviously greater than that of the physical mixture. The dissolution rate of NMDP(L) of the physical mixture was higher than that of NMDP(H). The dissolution rate of the different polymorphic forms of nimodipine from NMDP PEG6000 solid dispersion has no significant difference. The dissolving percentage(%) of NMDP from NMDP(H) PVP k 30 at tablet 90 minute is lower than that from NMDP(L) PVP k 30 tablet.CONCLUSION:The dissolution rate of NMDP can be improved greatly by coevaporation methods with PVP k 30 and PEG6000 as carriers.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2002年第6期484-486,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
制备
尼莫地平
不同晶型
溶出速率
固体分散物
nimodipine, Different polymorphic forms, dissolution rate, solid dispersion
