摘要
本文采用紫外分光光度法（λｍａｘ＝３１４ｎｍ）对国产六个厂家生产的盐酸雷尼替丁胶囊进行了体外溶出度测定。求得的Ｔ５０、Ｔｄ等参数具有显著差异（Ｐ＜０．０１）。六批只有四批累积溶出达８０％以上，且临床使用疗效不一，提示国产盐酸雷尼替丁胶囊有必要增加溶出度检查以控制其质量。
his paper describes the test of dissolution rate of Ranitidine Hydrochloride Capoules manufactured by six factorise withspectrophotometry(λmax 314nm).The parameters(T50、Td,etc)of these samples had very significant difference(P<0.01).Only four of the six batches met the requirement of 80%. Curative effects were different too,It indicates that it is nec-essary to make dissolution test for Ranitidine Hydrochloride Capsules to control the quality.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1994年第9期408-410,共3页
Chinese Journal of Hospital Pharmacy
关键词
盐酸雷尼替丁
胶囊
溶出度
比色法
ranitidine hydrochloride,dissolution rate,UV spectrophotometry
