摘要
磁波生物学非热效应的一个代表性事例是对离子 ,比如Ca2 + 穿越细胞膜的影响 ,从而导致细胞内外离子浓度比值发生变化。阐述电磁波对细胞离子浓度影响这一生物学非热效应的基本理论 ,以此为电磁波生物学非热效应机理研究提供理论基础。该基本理论基于两个角度 :一是物理学角度 ,即视生物组织和细胞膜为一般的电磁媒质 ,由物理学角度分析可看出 ,一定参数的电磁波可使细胞内外二价离子浓度的比值发生 10 -6量级的变化 ,这相当于正常细胞内外钙离子浓度在固有比值 10 -4 的基础上发生了 1%的变化 ,与细胞产生动作电位时需要细胞内外电荷密度的比值在固有的 10 -4 基础上发生 1%的变化比较 ,可知基于物理学角度 ,电磁波在引起生物学非热效应方面是有意义的 ;二是生物学角度 ,即视生物组织和细胞膜为特殊的生命物质 ,由生物学角度分析可看出 ,一定参数的电磁波可导致在 1秒钟内有 10 6量级的二价离子穿过细胞膜 ,与用趋化 (趋药 )性试验证明了的要使白细胞的生活状态发生有意义变化需要额外有 10 3 量级的分子通过细胞膜比较 ,可知基于生物学角度 ,电磁波在引起生物学非热效应方面也是有意义的 ,因为无论是细胞内外离子浓度的变化 ,还是电荷穿越细胞膜迁移所携带的信息都会改变细胞自身的生理和生化状态。
A representative fact in athermal effects of electromagnetic wave on biology is the influence upon transmembrane movement of ions, such as the movement of Ca 2+, which causes a change in the ratio between concentrations of intracellular and extracellular ions. This paper discusses the basic theory for the athermal effects related to the change in the ion concentration caused by electromagnetic wave (EMW), so as to provide theoretical foundation for studying the mechanism of athermal effects of EMW on cells. This theory is based on two aspects. The first aspect is based on physics, in the view that biological tissue and cell membrane are regarded as general electromagnetic media, when they interact with EMW, the amount of change of ratio between concentrations of intracellular and extracellular ions is about 10 -6, which is similar to 1% of the inherent ratio (10 -4) between concentrations of intracellular and extracellular Ca 2+ in a normal cell. Comparing with the 1% change which is requisite to produce action potential, it is in accor-dance with the change of a ratio of surface charge densitieson both sides of the cell membrane from inherent 10 -4 to 10 -6 order, it could be known that EMW is significant in producing athermal bioeffects based on the aspect of physics. The second aspect is based on biology, in the view that biological tissue and cell membrane are regarded as special living materials, when they interact with EMF, about 10 6 bivalent ions pass through the cell membrane in 1 second. Comparing with the requirement of additional about 10 3 ions passing through cell membrane to cause significant change in living states of white cell, which has been confirmed by chemotaxis experiment, it could be known that EMF is also significant in producing athermal bioeffects based on the aspect of biology, because the physiology and biochemistry states of cell will be changed both by changes of ions concentration in cell or by the information carried by trans-membrane movement of ions.
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
2002年第6期552-556,共5页
Chinese Journal of Biomedical Engineering
基金
国家自然科学基金资助项目 ( 30 170 2 40 )
陕西省自然科学基金资助项目 ( 2 0 0 1X0 1)
关键词
电磁波
生物学效应
离子浓度
非热效应
Electromagnetic wave
Bioeffects
Ion concentration
Mechanism of bioeffects
