摘要
目的探究益心康泰联合硝苯地平治疗冠心病心绞痛的临床效果与安全性。方法选取2014年6月—2016年3月在河南省人民医院就诊的冠心病心绞痛患者120例,随机分为对照组和治疗组,每组各60例。对照组口服硝苯地平片,2片/次,3次/d。治疗组患者在对照组治疗基础上口服益心康泰胶囊,2粒/次,3次/d。两组患者均连续治疗2个月。观察两组的临床疗效,比较两组治疗前后血清学指标、西雅图心绞痛量表评分和症状积分的变化情况。结果治疗后,对照组和治疗组的总有效率分别为81.67%、95.00%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清脂蛋白a、肌钙蛋白I和C反应蛋白水平均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组血清脂蛋白a、肌钙蛋白I和C反应蛋白水平均显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组西雅图心绞痛量表评分显著升高,而症状积分显著降低,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组西雅图心绞痛量表评分显著高于对照组,而症状积分低于对照组,两组比较差异具有统计学意义(P<0.05)。结论益心康泰联合硝苯地平治疗冠心病心绞痛疗效显著,可显著降低血清生化指标和症状评分,提高西雅图心绞痛量表评分,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy and safety of Yixin Kangtai Capsules combined with nifedipine in treatment of coronary heart disease angina pectoris. Methods 120 Patients with coronary heart disease angina pectoris in Henan Provincial People’s Hospital from June 2014 to March 2016 were randomly divided into control(60 cases) and treatment(60 cases) groups. Patients in the control group were po administered with Nifedipine Tablets, 2 tablets/time, three times daily. Patients in the treatment group were po administered with Yixin Kangtai Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacy was evaluated, and the changes of serological indicators, seattle angina scale score and symptom score in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 81.67% and 95.00%, and there were differences between two groups(P < 0.05). After treatment, lipoprotein a, troponin I and CRP in the two groups were significantly decreased, and there were differences in the same group(P < 0.05). After treatment, lipoprotein a, troponin I and CRP in the treatment group were lower than those in the control group, and there were differences between two groups(P < 0.05). After treatment, seattle angina scale score in the two groups was significantly increased, but symptom score was significantly decreased, and there were differences in the same group(P < 0.05). After treatment, seattle angina scale score in the treatment group was higher than that in the control group, but symptom score was significantly lower than that in the control group, and there were differences between two groups(P < 0.05).ConclusionYixin Kangtai Capsules combined with nifedipine has significant effect in treatment of coronary heart disease angina pectoris, and can significantly reduce serum biochemical indicators and symptom score, and also can improve s
作者
丁守坤
郭雷生
赵宗磊
杜娟娟
王丽霞
DING Shou-kun;GUO Lei-sheng;ZHAO Zong-lei;DU Juan-juan;WANG Li-xia(Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou 450003, China)
出处
《现代药物与临床》
CAS
2019年第1期59-62,共4页
Drugs & Clinic
