摘要
肝细胞癌是一种常见的消化道恶性肿瘤,尽管近年来在治疗方面取得了一定进展,但它仍然是全球死亡率较高的恶性肿瘤之一。随着对肝细胞癌分子机制研究的不断深入,推动了基于分子特征的个性化精准治疗,为患者带来了新的希望。本文将从肝细胞癌发生发展的驱动因素、分子分类与亚型、靶向免疫治疗现状及临床前模型开发四个方面,阐述精准医疗在肝细胞癌治疗中的实践应用与未来发展前景。
Hepatocellular carcinoma(HCC)is a common malignant tumor of the digestive system.Although there have been some advances in the treatment of HCC in recent years,it remains one of the cancers with a high global mortality rate.With the continuous deepening of research into the molecular mechanisms of HCC,personalized precision treatment based on the molecular characteristics of patients with HCC offers new hope.This article will discuss the practical application and future development prospects of precision medicine in the treatment of HCC from four aspects:driving factors of HCC,molecular classification and subtypes,the status of targeted immunotherapy,and preclinical models.
作者
王红阳
陈磊
姚汝铖
Wang Hongyang;Chen Lei;Yao Rucheng(National Center for Liver Cancer,Shanghai 201805;Department of Hepatobiliary and Pancreatic Surgery,Yichang Central People's Hospital,The First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,China)
出处
《巴楚医学》
2024年第4期1-12,共12页
Bachu Medical Journal
基金
国家自然科学基金区域创新发展联合基金项目(No:U21A20376)。
关键词
肝细胞癌
基因变异
靶向免疫治疗
精准医疗
hepatocellular carcinoma(HCC)
genetic variation
targeted immunotherapy
precision med-icine
