摘要
E2F2s是一种重要的转录因子,与消化道肿瘤的发生和发展密切相关。消化道肿瘤是一类常见的恶性肿瘤,包括食管癌、胃癌、结直肠癌等,严重威胁人们健康。研究表明,E2F2s在消化道肿瘤中起关键作用。E2F2s调控细胞周期转变和基因表达,影响细胞增殖和凋亡。E2F2s异常表达与消化道肿瘤的发生和转移密切相关。研究发现,E2F2s可以通过调控多种信号通路影响消化道肿瘤细胞的增殖和迁移能力,消化道包括Rb信号通路、p53信号通路、Wnt/β-catenin信号通路等。E2F2s通过调控多种信号通路影响肿瘤细胞的生物学行为,为消化道肿瘤的治疗提供了新的靶点和策略。
E2F2s is an important transcription factor,which is closely related to the occurrence and development of digestive tract tumors.Gastrointestinal malignant tumor is a kind of common malignant tumor,including esophageal cancer,gastric cancer,colorectal cancer,etc.,which seriously threatens people’s health.Studies have shown that E2F2s plays a key role in digestive tract tumors.E2F2s regulates cell cycle transition and gene expression,and influences cell proliferation and apoptosis.The abnormal expression of E2F2s is closely related to the occurrence and metastasis of digestive tract tumors.Studies have shown that E2F2s can affect the proliferation and migration ability of tumor cells through a variety of signaling pathways,including Rb signaling pathway,p53 signaling pathway,Wnt/β-catenin signaling pathway,and so on.As an important transcription factor,E2F2s affects the biological behavior of tumor cells by regulating various signaling pathways,providing new targets and strategies for the treatment of gastrointestinal malignant tumor.
作者
杨帅
闫文娴
朱超
赵文飞
冯青青
赵文文
魏红梅
YANG Shuai;YAN Wenxian;ZHU Chao;ZHAO Wenfei;FENG Qingqing;ZHAO Wenwen;WEI Hongmei(School of Clinical Medicine,Department of Medicine,Qingdao University/Qingdao Central Hospital,University of Health and Rehabilitation Sciences(Qingdao Central Hospital),Qingdao 266000,China)
出处
《临床肿瘤学杂志》
CAS
2024年第11期1114-1120,共7页
Chinese Clinical Oncology
关键词
消化道肿瘤
E2Fs
靶基因
治疗靶点
Gastrointestinal neoplasms
E2Fs
Target gene
Therapeutic target
