苍附导痰汤联合枸橼酸氯米芬治疗痰湿阻滞型多囊卵巢综合征不孕症患者的效果

Effects of Cangfu Daotan decoction combined with Clomiphene citrate in treatment of patients with polycystic ovary syndrome infertility of phlegm-damp stagnation type

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摘要目的:观察苍附导痰汤联合枸橼酸氯米芬治疗痰湿阻滞型多囊卵巢综合征不孕症患者的效果。方法:选取2021年12月至2022年11月该院收治的74例痰湿阻滞型多囊卵巢综合征不孕症患者进行前瞻性研究,按照随机数字表法将其分为研究组与对照组各37例。对照组采用枸橼酸氯米芬治疗,研究组在对照组基础上联合苍附导痰汤治疗,比较两组临床疗效,治疗前后性激素指标[卵泡刺激素(FSH)、雌二醇(E_(2))、黄体生成素(LH)]水平、卵巢体积、中医证候积分,排卵率,妊娠率,以及不良反应发生率。结果:研究组治疗总有效率为89.19%(33/37),高于对照组的70.27%(26/37),差异有统计学意义(P<0.05);治疗后,两组FSH、LH、E_(2)水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组双侧卵巢体积均小于治疗前,且研究组小于对照组,差异有统计学意义(P<0.05);研究组排卵率和妊娠率均高于对照组,差异有统计学意义(P<0.05);两组月经失调、体丰多毛、神疲肢重等中医证候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:苍附导痰汤联合枸橼酸氯米芬治疗痰湿阻滞型多囊卵巢综合征不孕症患者可提高治疗总有效率、排卵率、妊娠率和性激素指标水平,缩小卵巢体积,以及降低中医证候积分的效果优于单纯枸橼酸氯米芬治疗。 Objective:To observe effects of Cangfu Daotan decoction combined with Clomiphene citrate in treatment of patients with polycystic ovary syndrome infertility of phlegm-damp stagnation type.Methods:A prospective study was conducted on 74 patients with polycystic ovary syndrome infertility of phlegm-damp stagnation type admitted to this hospital from December 2021 to November 2022.They were divided into study group and control group according to the random number table method,37 cases in each group.The control group was treated with Clomiphene citrate,while the study group was treated with Cangfu Daotan decoction on the basis of that of the control group.The clinical efficacy,the sex hormone indexes[follicle stimulating hormone(FSH),estradiol(E_(2)),luteinizing hormone(LH)]levels and the TCM syndrome score before and after the treatment,the ovarian volume,the ovulation rate,the pregnancy rate,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 89.19%(33/37),which was higher than 70.27%(26/37)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FSH,LH and E_(2)in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The bilateral ovarian volume levels of the two groups were smaller than those before the treatment,those in the study group were smaller than those in the control group,and the difference was statistically significant(P<0.05).The ovulation rate and the pregnancy rate of the study group were higher than those of the control group,and the differences were statistically significant(P<0.05).The scores of TCM syndromes such as menstrual disorders,body fat and hairy,mental fatigue and limb heaviness in the two groups were lower than those before the treatment,those in the study group were lower than the control group,and the differences were st

作者雒秀娟 LUO Xiujuan(Department of Obstetrics and Gynecology of Zhengzhou Daqiao Hospital,Zhengzhou 450000 Henan,China)

机构地区郑州大桥医院妇产科

出处《中国民康医学》 2024年第24期86-89,共4页 Medical Journal of Chinese People’s Health

关键词苍附导痰汤枸橼酸氯米芬痰湿阻滞型多囊卵巢综合征不孕症性激素妊娠率中医证候积分 Cangfu Daotan decoction Clomiphene citrate Phlegm-damp stagnation type Polycystic ovary syndrome infertility Sex hormone Pregnancy rate TCM syndrome score

分类号 R711 [医药卫生—妇产科学]