摘要
目的探讨氧化应激与多囊卵巢综合症(PCOS)的关系,并观察维生素E(VE)、维生素C(VC)对PCOS的治疗作用。方法分别测定60例PCOS患者(PCOS组1和PCOS组2各30例)及30例健康自愿者(对照组)血清中脂质过氧化物(LPO)、丙二醛(MDA)、超氧化物岐化酶(SOD)、VE、VC的含量。PCOS组于抽血检测上述指标后,常规接受"炔雌醇环丙孕酮"治疗,PCOS组1同时服用抗氧化剂VE0.1gqd,VC0.2gbid,疗程3个月。在疗程结束的第7d,复查两组患者血清中LPO、MDA、SOD、VE、VC含量,并继续随访3个月,观察PCOS组1和PCOS组2患者月经自然恢复情况。结果与对照组比较,PCOS患者治疗前血清LPO、MDA含量明显升高(P均<0.05),SOD、VE、VC含量明显降低(P均<0.05);接受治疗后,PCOS组1患者血清氧化水平指标(LPO、MDA)含量较治疗前明显下降(P均<0.05),抗氧化能力指标(SOD、VE、VC)含量明显上升(P均<0.05);PCOS组2患者治疗前后血清氧化水平指标和抗氧化能力指标均无明显变化(P>0.05);治疗后,PCOS组1血清中LPO、MDA含量较PCOS组2降低(P均<0.05),SOD、VE、VC含量较PCOS组2升高(P均<0.05);PCOS组1月经自然恢复的情况明显优于组2患者(P<0.05)。结论PCOS的发病可能与氧化应激(活性氧的代谢失衡)有关,抗氧化剂可能改善PCOS患者的预后。
Objective To investigate the correlation between oxidative stress and PCOS, to provide an evidence for the treatment of PCOS. Methods The levels of maternal serum LPO, MDA, SOD, VE and VC were measured in 30 patients with PCOS （PCOS group 1） and in 30 normal women （control group） by chemicalorimetry. After being measured, the patients with PCOS （PCOS group 1） took VE 0. 1 qd × 3 months ,VC 0. 2 bid × 3 months and Diane-35 （Ethinylestradiol and Cyproterone Acetate Tablets）1 # qd × 21 d/month × 3 months. The LPO, MDA, SOD, VE and VC were measured after three months. The other 30 patients with PCOS （PCOS group 2） were chosen to take Diane-35 （Ethinylestradiol and Cyproterone Acetate Tablets）1 # qd × 21 d/month × 3 months only. The menstrual cycles were viewed in PCOS group 1 and PCOS group 2 for three months. Results The levels of maternal serum LPO and MDA in patients with PCOS （PCOS group 1） were significant higher than that in normal women （control group） （P〈0. 05）. The levels of maternal serum VE,VC and SOD in patients with PCOS （PCOS group 1） were lower than that in normal women （control group） （P〈 0. 05）. The levels of LPO and MDA after taking Diane-35,VE and VC were lower than that before taking Diane- 35,VE and VC. The levels of VE,VC and SOD after taking Diane-35,VE and VC were higher than that before taking Diane-35,VE and VC. The recoveries of menstrual cycles in PCOS group 1 were better than that in PCOS group 2. Conclusion The PCOS may be related to oxidative stress （the metabolism imbalance of reactive oxygen species）. The antioxidants may improve the prognosis of PCOS.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2008年第3期421-423,共3页
Journal of Sichuan University(Medical Sciences)
