摘要
目的:探究猪肺磷脂注射液联合无创高频振荡通气(HFOV)对新生儿呼吸窘迫综合征(NRDS)早产儿肺表面活性蛋白A(SP-A)及肺循环功能的影响。方法:选取2022年3月—2024年2月江西省妇幼保健院新生儿科收治的120例NRDS早产儿,以随机数字表法分为对照组、观察组,各60例。在常规治疗基础上,对照组予以无创HFOV治疗,观察组予以猪肺磷脂注射液联合无创HFOV治疗。比较两组的疗效、治疗前后SP-A水平、肺循环功能指标[平均肺动脉压(MPAP)、肺血管阻力(PVR)、血管外肺水量(EVLW)]。结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组SP-A、MPAP、PVR、EVLW均低于治疗前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。结论:猪肺磷脂注射液联合无创HFOV治疗NRDS早产儿,可提高疗效,降低患儿SP-A水平,改善肺循环功能,具有一定价值。
Objective:To explore the effects of Poractant Alfa Injection combined with non-invasive high frequency oscillatory ventilation(HFOV)on pulmonary surfactant protein A(SP-A)and pulmonary circulatory function in premature infants with neonatal respiratory distress syndrome(NRDS).Method:A total of 120 premature infants with NRDS admitted to the Neonatology Department of Jiangxi Maternal and Child Health Hospital from March 2022 to February 2024 were selected and divided into control group and observation group by random number table method,with 60 cases in each group.On the basis of conventional treatment,the control group was treated with non-invasive HFOV,and the observation group was treated with Poractant Alfa Injection combined with noninvasive HFOV.The therapeutic effect,SP-A level,pulmonary circulatory function indexes[mean pulmonary artery pressure(MPAP),pulmonary vascular resistance(PVR)and extravascular lung water(EVLW)]before and after treatment of the two groups were compared.Result:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,SP-A,MPAP,PVR and EVLW in two groups were lower than those before treatment,and those in observation group were lower than those in control group,the differences were statistically significant(P<0.05).Conclusion:Poractant Alfa Injection combined with non-invasive HFOV in the treatment of premature infants with NRDS can improve the curative effect,reduce the level of SP-A and improve the pulmonary circulation function, which has certain value.
作者
严丽丽
王海燕
曾小波
周锦龙
YAN Lili;WANG Haiyan;ZENG Xiaobo;ZHOU Jinlong(Department of Neonatology,Jiangxi Maternal and Child Health Hospital,Nanchang 330000,China;不详)
出处
《中国医学创新》
CAS
2024年第36期22-25,共4页
Medical Innovation of China
基金
江西省卫生健康委科技计划项目(202130840)。
关键词
新生儿呼吸窘迫综合征
无创高频振荡通气
猪肺磷脂
肺表面活性蛋白A
肺循环功能
Neonatal respiratory distress syndrome
Non-invasive high frequency oscillation ventilation
Poractant
Alfa Pulmonary surfactant protein A
Pulmonary circulation function
