摘要
目的比较比例辅助通气（PAV）、高频振荡通气（HFOV）、同步间歇指令通气（SIMV）治疗新生儿呼吸窘迫综合征（NRDS）的疗效。方法采用回顾性研究，对2008年5月至2012年5月在江门市中心医院使用过PAV、HFOV、SIMV3种机械通气模式之一治疗，且符合病例纳入标准的161例NRDS患儿的临床资料进行分析，按照使用呼吸机的通气模式不同分为3组，比较其疗效。结果PAV组采用PAV治疗43例，HFOV组采用HFOV治疗58例，SIMV组采用SIMV治疗60例，3组间性别、出生胎龄、出生体质量、使用固尔苏剂量比较差异均无统计学意义（P均〉0．05）；PAV组、HFOV组、SIMV组治疗有效病例分别为37例、57例、52例，无效病例分别为6例、1例、8例，3组疗效比较差异有统计学意义（X^2=6．197，P=0．045），其中PAV组与SIMV组比较差异无统计学意义（X^2=0．008，P=0．928），HFOV组明显优于PAV组与SIMV组（X^2=3．986，P=0．046；X^2=4．114，P=0．043）。结论HFOV治疗NRDS的疗效较好，可以作为优先选择。
Objective To contrast the curative effects of proportional assist ventilation （PAV） and high frequency oscillatory ventilation（HFOV） and synchronized intermittent mandatory ventilation（SIMV） on treatment of neonatal respiratory distress syndrome （NRDS）. Methods A retrospective study was carried out based on clinical data of 161 neonates. The research subjects were the neonates who had been hospitalized from May 2008 to May 2012 in Jiang- men Central Hospital and received one of the mechanical ventilation methods. The subjects were divided into 3 groups according to used mechanical ventilation mode they received, and their curative effect was compared. Results Forty- three cases in PAV group were treated by PAV,58 cases in HFOV group received HFOV ,and 60 cases in SIMV group received SIMV. In comparison with sex ratio, gestational age of birth,birth weight, dose of poractant alfa injection there was no differece among 3 groups （ all P 〉 0.05 ）. The number of effective cases in PAV group, HFOV group and SIMV group was 37 cases, 57 cases,52 cases, respectively; the invalid cases including 6 cases, 1 case, 8 cases in 3 groups, re~ spectively. Among the 3 groups,the curative effect was significantly different（x2 =6. 197,P =0.045） ,curative effect of PAV group was not different from that of SIMV group（X^2 =0.008 ,P =0.928） ,curative effect of HFOV group was better than that of PAV group and SIMV group （X^2 = 3. 986, P = 0. 046 ;X^2 = 4.114, P = 0.043 ）. Conclusion The curative effect of HFOV for neonatal respiratory distress syndrome was better,which could be recommended.
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2013年第2期124-126,共3页
Chinese Journal of Applied Clinical Pediatrics
基金
广东省医学科学基金资助课题（2008003）
关键词
比例辅助通气
高频振荡通气
同步间歇指令通气
呼吸窘迫综合征
婴儿
新生
Proportional assist ventilation
High frequency oscillatory ventilation
Synchronized intermittent mandatory ventilation
Respiratory distress syndrome
Infant, newborn
