摘要
目的分析在肥胖2型糖尿病(type 2 diabetes mellitus,T2DM)患者的临床治疗中,瑞格列奈和德谷胰岛素的联合应用效果。方法选取2021年6月—2024年6月宁化县总医院收治的80例肥胖T2DM患者为研究对象,按照不同治疗方法分为两组,对照组(34例)采用德谷胰岛素治疗,研究组(46例)在对照组基础上联用瑞格列奈治疗。比较两组临床疗效、糖脂代谢水平、胰岛功能、不良反应发生情况。结果研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组空腹胰岛素、胰岛β细胞功能指数、高密度脂蛋白水平均高于对照组,空腹血糖、餐后2 h血糖、糖化血红蛋白、胰岛素抵抗指数、低密度脂蛋白、甘油三酯、总胆固醇水平均低于对照组,差异均有统计学意义(P均<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论在肥胖T2DM的临床治疗中,瑞格列奈和德谷胰岛素联合应用能够有效控制患者的血糖指标,调节机体糖脂代谢,增强胰岛功能,减轻胰岛素抵抗,治疗安全性和实用性较高。
Objective To analyze the combined effect of repaglinide and insulin degludec in the clinical treatment of obese patients with type 2 diabetes mellitus(T2DM).Methods A total of 80 obese T2DM patients admitted to Ninghua County General Hospital from June 2021 to June 2024 were selected as the research objects and divided into two groups according to different treatment methods.The control group(34 cases)was treated with insulin degludec,and the study group(46 cases)was treated with repaglinide on the basis of the control group.The clinical efficacy,levels of glucose and lipid metabolism,islet function and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).After treatment,the levels of fasting insulin,isletβ-cell function index and high-density lipoprotein in the study group were higher than those in the control group,and the levels of fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin A1c,insulin resistance index,low-density lipoprotein,triglyceride and total cholesterol were lower than those in the control group,the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In the clinical treatment of obese T2DM,the combined application of repaglinide and insulin degludec can effectively control the blood glucose index of patients,regulate the body's glucose and lipid metabolism,enhance islet function,and reduce insulin resistance,and the treatment is safe and practical.
作者
张达发
伊昭钿
俞祖宁
ZHANG Dafa;YI Zhaodian;YU Zuning(Department of General Medicine,Ninghua County General Hospital,Sanming 365400,Fujian,China;Department of Endocrinology,Ninghua County General Hospital,Sanming 365400,Fujian,China;Department of Neurology,Nin-ghua County General Hospital,Sanming 365400,Fujian,China)
出处
《糖尿病新世界》
2024年第20期52-55,共4页
Diabetes New World
关键词
瑞格列奈
德谷胰岛素
肥胖2型糖尿病
胰岛功能
糖脂代谢
Repaglinide
Insulin degludec
Obese type 2 diabetes mellitus
Islet function
Glucose and lipid metabolism
