摘要
目的探讨利拉鲁肽治疗2型糖尿病伴肥胖患者对体重指数、血糖水平、微炎症水平及脂质水平的干预作用。方法选择2017年1月至2019年1月内分泌科治疗的2型糖尿病伴肥胖患者81例,随机分为对照组40例和观察组41例。对照组口服二甲双胍片治疗,观察组在对照组基础上使用皮下注射利拉鲁肽治疗,连续治疗12周后,对比2组的体质指标、血糖各指标、微炎症指标、脂质指标。结果2组治疗前腰围、臀围、腰臀比、BMI差异无统计学意义(P>0.05),观察组治疗12周后腰围、臀围、BMI明显小于对照组,而腰臀比明显大于对照组(P<0.05);观察组治疗12周后FPG、2 h PG、HbA1c、HOMA-IR均低于对照组(P<0.05);观察组治疗12周后AASA、IL-6、TNF-α水平明显低于对照组(P<0.05);观察组治疗12周后TC、TG、LDL-C水平明显低于对照组,而HDL-C水平明显高于对照组(P<0.05)。结论利拉鲁肽治疗2型糖尿病伴肥胖患者具有良好效果,能够有效降糖、降脂、降低体重指数(BMI)、减轻微炎症水平,有助于改善病情结局,具有积极的临床意义。
Objective To investigate the intervention effects of liraglutide in treatment of type 2 diabetes mellitus patients with obesity and its effects on the body mass index,blood glucose level,micro-inflammation and lipid levels.Methods A total of 81 patients with type 2 diabetes mellitus complicated by obesity who were treated in our hospital from January 2017 to January 2019 were randomly divided into control group(n=40)and observation group(n=41).The patients in control group were treated by oral metformin tablets,however,the patients in observation group,on the basis of control group,were treated by subcutaneous injection of liraglutide,with a treatment course of 12 weeks for both groups.The body mass indexes[waistline,hip circumference,waist hip ratio,body mass index(BMI),blood sugar each indexes[fasting plasma glucose(FPG),2h postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c),insulin resistance indexes(HOMA IR)],micro inflammation indexes[serum amyloid protein A(AASA),interleukin 6(IL-6),tumor necrosis factor alpha(TNF alpha)],lipid indexes[total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)]were observed and compared between the two groups.Results Before treatment there were no significant differences in waist circumference,hip circumference,waist-to-hip ratio and BMI between the two groups(P>0.05).After 12week-treatment,the waist circumference,hip circumference and BMI in observation group were significantly lower than those in control group,however,the waist-to-hip ratio was significantly higher than that in control group(P<0.05).And the levels of FPG,2hPG,HbA1c,HOMA-IR and AASA,IL-6,TNF-αas well as TC,TG,LDL-C in observation group were significantly lower than those in control group(P<0.05),however,the HDL-C levels were significantly higher than those in control group(P<0.05).Conclusion The liraglutide has obvious effects in treatment of type 2 diabetes mellitus complicated by obesity,which can effectively decrease sugar,f
作者
王晶璞
卢燕
王会
WANG Jingpu;LU Yan;WANG Hui(Baoding Second Hospital,Hebei,Baoding 071000,China)
出处
《河北医药》
CAS
2021年第9期1389-1391,1395,共4页
Hebei Medical Journal
基金
保定市科学技术研究与发展计划项目(编号:1951ZF010)。
关键词
2型糖尿病
肥胖
利拉鲁肽
体重指数
血糖
微炎症
脂质
type 2 diabetes
obesity
liraglutide
body mass index
blood sugar
micro inflammation
lipid
